Objective: The aim of this study was to investigate the effects of intravenous magnesium sulfate on the prevention of pain during the injection of microemulsion propofol. Magnesium is a known calcium channel blocker and a physiological N-methyl-D-aspartate receptor antagonist. Methods: American Society of Anesthesiologists I and II adults (n= 114) undergoing general anesthesia for surgery were ...

To formulate a compatible green medium for the conversion of a hydrophobic substrate by a hydrophilic enzyme, we investigated the phase behavior of pseudo ternary hydrophobic ionic liquid (HIL)/buffer/polyoxyethylene-type nonionic surfactant (CnEm)/n-alcohol system and the effects of the components on the formulation of the HIL-based bicontinuous microemulsion. It is found that small head group...

We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin. Skin accumulation as well as the solubility of chlorogenic acid in aqueous vehicles was much greater than for other polyphenols such as quercetin and genistein. However, since enhancement of skin delivery seemed to be necessary to ex...

short timeframe, and rapid approaches are needed to assess log Pow values of these compounds (2,4,7). Several separation-based approaches for indirectly determining log Pow values in a rapid fashion have been reported, including reversed-phase high performance liquid chromatography (HPLC) (2,3,8–11), thin-layer chromatography (12,13), micellar electrokinetic chromatography (MEKC) (7,14–16), and...

We recall briefly the knowledge on microemulsion structure emphasizing the importance of the surfactant layer properties. We present results of experiments made with water-alkanenon-ionic surfactants systems that, together with results obtained earlier in other systems, confirm the close relationship between the maximum characteristic size in the microemulsion and the persistence length of the ...

The aim of this study was to develop suitable microemulsion gel systems for transdermal delivery that could assist dissolution enhancement of poorly water soluble celecoxib and thus improve its skin permeability. Long term oral administration of celecoxib causes serious gastrointestinal adverse effects, which makes it a good candidate for transdermal formulations, yet its low water solubility (...

A new approach based on microemulsions formulated with at least 85% water and minority components consisting of oil (limonene) and surfactant (anionic and nonionic) is demonstrated for the first time to be effective for flooding wood's complex capillary structure. The formulation of the microemulsion was based on phase behavior scans of Surfactant-Oil-Water systems (SOWs) and the construction o...

T h e effect of Polyacrylamide as an additive on preparat ion of inverse microemulsion t o l u e n e — A O T ( A O T sodium bis(2-ethylhexyl)sul fosuccinate)—water—acrylamide—Polyacrylamide and on t h e propert ies of polymer particles resulting from t h e free-radical polymerizat ion of acrylamide was s tudied. I t was found t h a t the a m o u n t of Polyacrylamide which can be added wi thout...

Sulfur nanoparticles were synthesized from hazardous H2S gas using novel biodegradable iron chelates in w/o microemulsion system. Fe–malic acid chelate (0.05 M aqueous solution) was studied in w/o microemulsion containing cyclohexane, Triton X-100 and n-hexanol as oil phase, surfactant, co-surfactant, respectively, for catalytic oxidation of H2S gas at ambient conditions of temperature, pressur...