MICRODOSIMETRY..AND THE THEORY OF STRAGGLING. Theoretical developments in microdosimetry (the determination of the spatial distribution of energy deposition on a microscopic scale) are described. It is pointed out that microdosimetric theory is equivalent to LET theory plus straggling theory. The influence of each of the different random factors (varying LET, varying track length, varying numbe...

Three general m e t h o d s w h e r e b y we can i m p r o v e o u r u n d e r s t a n d i n g o f the b i o p h y s i c a l e f fect o f a phys i ca l agent are : (1 ) A t t e m p t t o f o l l o w t h e series o f processes t a k i n g place b e g i n n i n g w i t h the i n t e r a c t i o n o f the agent a n d t h e b i o l o g i ca l s ys t em. (2 ) T r y t o unrave l t h e causal cha in b...

Over the past decade, there has been progressively stronger interest in the use of a-particle emitters for radioimmunotherapy (1–6). With proper localization of the labeled antibody, the high linear energy transfer of a-particles provides a correspondingly high probability of mitotic cell kill when compared with an equivalent number of cellular traversals by lower linear energy transfer b-parti...

Over the past decade, there has been progressively stronger interest in the use of a-particle emitters for radioimmunotherapy (1–6). With proper localization of the labeled antibody, the high linear energy transfer of a-particles provides a correspondingly high probability of mitotic cell kill when compared with an equivalent number of cellular traversals by lower linear energy transfer b-parti...