Soils are arguably the most microbially diverse ecosystems. Physicochemical properties have been associated with the maintenance of this diversity. Yet, the role of microbial substrate specialization is largely unexplored since substrate utilization studies have focused on simple substrates, not the complex mixtures representative of the soil environment. Here we examine the exometabolite compo...

The induction of mineralization by microbes has been widely demonstrated but whether induced biomineralization leads to distinct morphologies indicative of microbial involvement remains an open question. For calcium carbonate, evidence suggests that microbial induction enhances sphere formation, but the mechanisms involved and the role of microbial surfaces are unknown. Here, we describe hydroz...

Two different doenjang manufacturing processes, the industrial process (IP) and the modified industrial process (mIP) with specific microbial assortments, were subjected to metabolite profiling using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). The multivariate analyses indicated that both primary and secondary metabolites ...

To produce an active metabolite of Chlordiazepoxide by fungal biotransformation in easy and economic way also to develop microbial models for drug metabolism studies. is metabolized the liver CYP3A4 forms major N-desmethyl chlordiazepoxide. The focus study was explore ability six distinct fungi biotransform its metabolites. Induction, Inhibition kinetic studies were conducted find out type capa...

Faecal microbiota transfer (FMT) consists of the infusion donor faecal material into intestine a patient with aim to restore disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on microbial composition, its functional capacity, metabolite profiles and their interactions in 16 irritable bowel syndrome (IBS) patients. samples from eight different time points bef...

The accelerating pace of microbial genomics is sparking a renaissance in the field of natural products research. Researchers can now get a preview of the organism's secondary metabolome by analyzing its genomic sequence. Combined with other -omics data, this approach may provide a cost-effective alternative to industrial high-throughput screening in drug discovery. In the last few years, severa...

The gut microbiota presented in the human digestive system plays an active role maintaining host health. Recent studies that rely on use of high throughput metagenomic sequencing (MGS) revealed association dysbiosis intestinal microbial community and many chronic diseases, specifically type 2 diabetes (T2D). This disease is considered one most prevalent metabolic diseases worldwide comprising u...