Tissue vasculature is altered when cancer develops. Consequently, noninvasive methods of monitoring blood vessel size, density, and oxygenation would be valuable. Simple spectroscopy employing fiber optic probes to measure backscattering can potentially determine hemoglobin parameters. However, heterogeneity of blood distribution, the dependence of the tissue-volume-sampled on scattering and ab...

Antiangiogenic agents transiently normalize tumor vessel structure and improve vessel function, thereby providing a window of opportunity for enhancing the efficacy of chemotherapy or radiotherapy. Currently, there are no reliable predictors or markers reflecting this vessel normalization window during antiangiogenic therapy. Apelin, the expression of which is regulated by hypoxia, and which ha...

Improved prevention and treatment of cardiovascular diseases is one of the challenges in Western societies, where ischemic heart disease and stroke are the leading cause of death. Early epidemiological studies have shown an inverse correlation between circulating high-density lipoprotein-cholesterol (HDL-C) and cardiovascular diseases. The cardioprotective effect of HDL is because of its abilit...

Previous reports indicate that in the Royal College of Surgeons (RCS) rat a decline in the retinal vessel density accompanies the loss of the normal architecture of the deep bed. This begins at about three months with neovascularization that originates in the deep vessel bed and develops in the direction of the retinal pigment epithelial (RPE) cells by four months. A surgical technique has been...

Time-dependent alterations in the ultrasonography characteristics of lymph nodes during early-stage metastasis have not been compared with those of tumor-draining lymph nodes that do not develop tumor; this is partly due to the absence of an appropriate experimental model. In a previous study of lymph nodes with experimental early-stage metastasis, we used contrast-enhanced high-frequency ultra...

The wood micro cellular structural constituents of five lesser used wood species in Nigeria among which are Butyrospermum paradoxum, Albizia zygia, Lanea acida, Parkia felicoida and Isoberlina doka are determined. Fibre cells accounts for 54% of the total wood micro cellular constituents of B. paradoxum while vessel, axial and ray parenchyma cells make up the rest of the wood micro structural c...

Functional high-density micro-arrays for mass spectrometry enable rapid picolitre-volume aliquoting and ultrasensitive analysis of microscale samples, for example, single cells.

Many diseases affect blood vessel morphology. This report analyzes vessel attributes (tortuosity, vessel density, radius, and terminal branch count) within 5 malignant gliomas as seen by high-resolution MR. Results are compared to those in the same anatomical region of 14 normal controls. All tumor patients had marked increases in vessel tortuosity and terminal branch count. These results raise...

There are many visualizations that show the trajectory of a moving object to obtain insights in its behavior. In this user study, we test the performance of three of these visualizations with respect to three movement features that occur in vessel behavior. Our goal is to compare the recently presented vessel density by Willems et al. [WvdWvW09] with well-known trajectory visualizations such as...