Kaempferol, a flavonoid, contains plethora of therapeutic properties and has demonstrated its efficacy against cancer. This study aims to unravel the molecular targets that are being modulated by kaempferol on HeLa cells. Various assays were performed, namely: MTT assay, flow cytometry analyze DNA content quantitate apoptosis. Quantitative PCR protein profiling performed evaluate manifestation ...

Background: Wogonin as a flavonoid compound is known for its anticancer effect through growth control, differentiation, and apoptosis. This study investigates the possible activity of wogonin in inducing cell death breast tumors MDA-MB231. Materials Methods: The level proliferation was evaluated by MTT assay. Cycle analysis apoptotic rate were assessed flow cytometry. mRNA Bax, Bcl-2, p53, surv...

CONCLUSION Down-regulation of the ratio of Mcl-1/Bax expression may contribute to age-related sensory cell degeneration in the cochlea. OBJECTIVE To better understand the involvement of Bcl-2 family members in the regulation of age-related sensory cell death, we examined the expression patterns of Bcl-2-associated protein X (Bax) and its suppressor, myeloid cell leukemia 1 (Mcl-1) in young an...

Alternatif tıpta kemoterapi benzeri tedavi yöntemlerine ek olarak sıklıkla bitkisel kökenli doğal ilaçlar kullanılmaktadır. Panax ginseng bunlardan biridir ve sinir sistemi kaynaklı hastalıklarda tercih edilmektedir. Çalışmamızda amaç, sisplatinden önce kullanılan ginsengin YKG1 glioblastoma hücrelerinde hücre ölümü canlılığı bakımından değerlendirilmesidir. Ticari satın alınan hücreleri, % 5 C...

The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experime...

This study was to investigate the effects of intracerebral hemorrhage (ICH) and subsequent minimally invasive hematoma aspiration on the expression of apoptosis-related genes in rats. IV-collagenase was injected to the caudate nucleus of the rats to make ICH models. In the control group, 30 Sprague-Dawley (SD) rats were mock treated with saline instead of collagenase. Thirty SD rats with succes...

Introduction: Previous studies have proven that secretory materials of mesenchymal stem cells (MSCs) (secretome) remedial properties. Objectives: The main goal this study was to evaluate the effects secretome adipose-derived MSCs on growth and apoptosis in anaplastic thyroid carcinoma (ATC) C-643 cells. Materials Methods: Initially, were exposed 25 50 μg/mL (ADSCs) for 24 48 hours, proliferatio...

Colon cancer (CRC) is one of the most common types in world. In this study, effects Tarantula cubensis alcoholic extract (TCAE) and Capecitabine CRC were investigated. Wistar albino rats divided into eight groups with 12 animals each group: untreated healthy groups, treated TCAE or Capecitabine, both Capecitabine. Azoxymethane was used all groups. administered to relevant starting 15th week. Al...