The objective: to study the genetic determinants of rifampicin resistance Mycobacterium tuberculosis by sequencing RRDR rpoB gene. Subjects and Methods. included 651 M. isolates that were tested for drug suceptibility (DST) genotypic methods (gDST) TB-TEST (BIOCHIP-IMB, Russia), Amplitube-MDR-RV (NPK Sintol, Russia) phenotypic (phDST): absolute concentration method, BACTEC MGIT 960 system, Sens...

The interest in the synthesis of metallic complexes of different drugs to make them moreefficient in biological environment of the human body is seen for the last few decades. Widerange of metal complexes are already used in clinical practice which encourages additionalresearch for innovating new metal based drugs, such as metal-mediated antibiotics, antiparasitic,antiviral, antibacterial, and ...

The interest in the synthesis of metallic complexes of different drugs to make them moreefficient in biological environment of the human body is seen for the last few decades. Widerange of metal complexes are already used in clinical practice which encourages additionalresearch for innovating new metal based drugs, such as metal-mediated antibiotics, antiparasitic,antiviral, antibacterial, and ...

Pyrazinamide (PZA) is a key antituberculosis drug, yet no rapid susceptibility test is commercially available. PZA drug susceptibility testing (DST) was performed directly on sputum samples from 327 patients and compared with the indirect method by using the Bactec MGIT 960 system in the context of patient screening for participation in a drug trial. Compared to standard indirect PZA DST, direc...