AIMS Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). METHODS In this prospective, randomized case control study, 577 cases...

PURPOSE To investigate the efficacy of candesartan 32 mg and hydrochlorothiazide (HCTZ) 25 mg combination in patients with severe essential hypertension. PATIENTS AND METHODS In this prospective, open-label, single-group study, 106 previously untreated patients with a baseline systolic blood pressure (SBP) of 150-200 mmHg, and a diastolic blood pressure (DBP) of 110 to 120 mmHg, started with ...

We have constructed the X 1 Σ + g potential for the collision between two ground state Mg atoms and analyzed the effect of uncertainties in the shape of the potential on scattering properties at ultra-cold temperatures. This potential reproduces the experimental term values to 0.2 cm −1 and has a scattering length of +1.4(5) nm where the error is prodominantly due to the uncertainty in the diss...

A double blind trial was conducted in seven centres to evaluate the safety and efficacy of cimetidine 800 mg given at night compared with 400 mg given at breakfast and at bedtime. Altogether 197 patients with active duodenal ulcer confirmed by endoscopy entered the study, of whom 187 were eligible for analysis. After four weeks' treatment the ulcer was healed in 76 of 91 patients (84%) receivin...

BACKGROUND Atazanavir plus raltegravir 300/400 mg twice daily is being explored as a ritonavir- and nucleoside-sparing treatment strategy. The pharmacokinetics and safety of this combination in healthy individuals were evaluated. METHODS A total of 22 healthy individuals received raltegravir 400 mg on days 1-5, atazanavir 300 mg on days 6-12 and atazanavir plus raltegravir 300/400 mg on days ...

The objective of the present work is to study the casting characteristics of various A1-Li alloys, which include fluidity and strengths of the alloys and their interaction with cast molds. Materials investigated are Al-Li-Mg and Al-Li-Cu-Mg alloys with Li content of 2.5 wt%. The results show that sand molds with resin binders are good for A1-Li casting. Ceramic coatings can further reduce the m...

BACKGROUND Reducing low-density lipoprotein cholesterol (LDL-C) is the primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD). METHODS This double blind placebo-controlled study enrolled patients 18 to 75 years of age with primary hypercholesterolemia and established CHD who were taking a stable daily dose of simvastatin 20 mg. Patients were randomized ...

There is variability in the Mg isotopic composition that is a reflection of the widespread heterogeneity in the isotopic composition of the elements in the solar system at approximately 100 ppm. Measurements on a single calcium-aluminum-rich inclusion (CAI) gave a good correlation of Mg ⁄ Mg with Al ⁄ Mg, yielding an isochron corresponding to an initial (Al ⁄ Al)o = (5.27 ± 0.18) · 10 and an in...