نتایج جستجو برای: methylenetetrahydrofolate reductase gene
تعداد نتایج: 1173819 فیلتر نتایج به سال:
Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like Glanzmann's t...
BACKGROUND AND OBJECTIVES Intrauterine growth restriction is an important cause of morbidity and mortality. Its pathogenesis is still a matter of debate. The aim of this study was to evaluate the association between intrauterine growth restriction (diagnosed in utero by serial ultrasound examinations and characterized by abnormal umbilical arterial Doppler velocimetry) and thrombophilic polymor...
abstract: methylenetetrahydrofolate reductase (mthfr) is a key enzyme regulating folate metabolism, which affects dna methylation and synthesis. one of the most important polymorphisms identified in the mthfr gene is c677t. mthfr activity is lowered in individuals with 677tt genotype. using pyrosequencing, we analyzed the mthfr genotypes in 118 colorectal cancer patients and 189 normal matched ...
BACKGROUND An association between depression and folate status has been demonstrated in clinical studies, whereas data are sparse on the relationship between depression and other components of 1-carbon metabolism such as vitamin B12, homocysteine, and the methylenetetrahydrofolate reductase 677C-->T polymorphism. The relationship between anxiety and these components is less well known. This stu...
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