a rise in serum alkaline phosphatase, glutamic oxaloacetic transaminase levels, and increased Bromsulphalein retention. Elevation of the serum bilirubin may occur. In its most benign form the condition is usually symptomless, but complaints, such as anorexia, abdominal pain, or pruritus, and signs, such as fever or hepatomegaly, may occur. Histologic changes similar to those of viral hepatitis ...

To the Editor: Alpha-methyldopa was introduced as an antihypertensive drug in 1960. Side effects of its administration have included dry mouth, fever, gastrointestinal upset, positive results on antinuclear antibody (ANA) tests and lupus erythematosus cell preparations, granulocytopenia and thrombocytopenia, positive direct Coombs’ test results, hemolytic anemia, and serious hepatic injury ( I ...