A series of novel bis(beta-cyclodextrin)s tethered with organoselenium linkers, i.e., 6,6'-(o-phenylene-diseleno)-bridged bis(beta-cyclodextrin) (2), 6,6'-[2,2'-diselenobis(benzoyloxy)]-bridged bis(beta-cyclodextrin) (3), and 6,6'-[2,2'-diselenobis[2-(benzoylamino)ethylamino]]-bridged bis(beta-cyclodextrin) (4), were synthesized from beta-cyclodextrin (1). The inclusion complexation behavior of...

background: the protein of niemann-pick type c1 (npc1) gene promotes the egress of cholesterol from late endosomes and lysosomes to other cellular compartments and contributes to a process known as reverse cholesterol transport. this study aimed to examine whether promoter methylation of npc1 is associated with risk of cardiovascular disease (cvd). methods: fifty cvd patients and 50 healthy sub...

background: this study intends to determine the diagnostic and prognostic roles of hypermethylation of serum rassf1a and protocadherin-10 promoters in females with breast cancer. methods: this study enrolled 80 breast cancer patients and 80 apparently normal healthy controls. the promoter methylation status of serum rassf1a and pcdh10 genes was investigated using methylation specific pcr. resul...

The cyclical structure of this molecule has been previously employed in various industries: In low fat dairy spreads, hydrophobic cholesterol is removed using a process by lodging it inside the cyclodextrin. Hydroxypropyl-β-cyclodextrin (HPβCD) is the principle active compound in the fabric odour eliminator Febreze, the cyclodextrin simply envelops any malodorous molecules leaving even my runni...

Lung administration of antibiotics by nebulization is promising for improving treatment efficiency for pulmonary infections, as it increases drug concentration at sites of infection while minimizing systemic side effects. For poorly soluble molecules like rifampicin, cyclodextrins (CD) may improve lung delivery by permitting higher dosing. For this purpose, we investigated rifampicin-CD complex...

tance to infection. Ways of protecting the surrounding skin vary enormously and are largely a matter of individual preference. Some people think the regular use of soap, methylated spirit and talcum powder?although often considered completely outdated?is still the most effective preventive method. A lot of its success must be because of the massage that goes with it, carried out with a circular...

We describe the complexation of isolated and native lipoproteins by natural macrocyclic polymers of glucose ("cyclodextrins"). Treatment of serum with cyclodextrin produces an immediate flocculation of the lipoproteins. The formation of cyclodextrin-lipoprotein complexes was evident on agarose electrophoresis gels. The concentration-dependent ability of alpha-cyclodextrin to precipitate chylomi...

Porous silica has been extensively used as suitable carrier for the immobilization of various enzymes. Randomly Methylated β-Cyclodextrin (RaMeβCD) surface active properties and very high solubility in water could therefore be template fabrication particles with tunable pore size. Silica were prepared by sol-gel process alkaline medium without use RaMeβCD. Lipase Bfrom Candida antarctica (CALB)...

Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal el...