Abstract Selenium containing drugs like selenomethionine, selenocystine, selenourea and methylseleninic acid are reported to exhibit potential anticancer effect. However, these may exert adverse effects when used over a prolonged period. Little is known about the interaction of selenium with vital erythroid protein hemoglobin. In this work comparative study organo-selenium hemoglobin heme moiet...

The normal presentation of a patient with a drug induced methemoglobinemia is a low pulse oximetry (SpO2) reading, usually in the mid 80% range, while having a very high PaO2 on an arterial blood gas (ABG)1. We present a case where the initial ABG showed a very high PaO2 and a metabolic alkalosis while the SpO2 fluctuated (85% 99%). Those findings combined with hemodynamic instability complicat...

Topical anesthetics, such as benzocaine, have been reported to cause methemoglobinemia, in which hemoglobin is unable to release oxygen effectively to body tissues. The pathophysiology, symptoms, and treatment of a 46-year-old patient are examined.

A juvenile male mixed breed dog was presented for lethargy, exercise intolerance, and aggression when touched on the head. Cyanosis, tachycardia, and tachypnea were observed and persisted during oxygen supplementation. Arterial blood gas analysis by co-oximetry identified an increased methemoglobin concentration (27%; normal, <2%) with normal arterial oxygen tension. The methemoglobinemia and a...

Prilocaine induced methemoglobinemia is a rare entity. In the present paper, the authors aim to draw attention to the importance of this rare condition by reporting this case. A 30-year-old female presented to Emergency Department with headache, dispnea and cyanosis. The patient has a history of 1000-1200 mg of prilocaine subcutaneous injection for hair removal at a beauty center, 5 hours ago. ...

Topical anesthetic drugs are widely used clinically during hospital and outpatient procedures and are easily available to the public in a variety of over-the-counter preparations. These anesthetic are especially popular and commonly used in many local dermatological clinics. Yet, topical anesthesia poses certain risks with pediatric patients, especially when a large area is covered. Furthermore...

OBJECTIVE The aim of this work was to establish reference values for methemoglobin levels in 6 to 10-year-old children. METHODS Methemoglobin concentrations were studied in clinically healthy children. The method for methemoglobin measurement used, neither uses highly toxic chemical compounds nor expensive enzymatic methods, thus it is feasible in the laboratory routine. RESULTS The results...

We herein present an autopsy case of fatal methemoglobinemia due to suicidal ingestion of sodium nitrite. A man in his 30s who had exhibited mild depression was found dead in his house. A glass containing a white turbid solution and a suicide note were found on the table near the decedent. At autopsy, the lividity of the face and back was greenish gray, and the blood was tinted a chocolate brow...