conclusions sleep quality showed a poorer profile than sexual function. therefore, more emphasis should be laid on treatment of sleep disparity during follow up of mmt patients comparing to their sexual function. patients should be reassured that probable sexual dysfunctions should not be regarded as a consequence of mmt. results mean ± sd age of the subjects was 41.2 ± 7.9 years and 93.4% of t...

BACKGROUND Intravenous drug misuse, principally heroin, occurs primarily in the Greater Dublin area. Methadone maintenance treatment has been an important part of the response to opiate misuse in Dublin since 1992. AIMS To determine the number of opiate-related deaths in Dublin City and County during 1999, to establish the number of methadone-related deaths and determine the proportion of dea...

In recent years, remarkable advances in sensitive analytical techniques have enabled the analysis of drugs in unconventional samples, such as sweat. In a study conducted during a methadone maintenance program, PharmChek sweat patches were applied to 20 subjects. The subjects were orally administered methadone in 1 dosage/day, and doses ranged from 80 to 100 mg. The sweat patch was applied 10 mi...

PURPOSE Methadone is a prescription drug used to help individuals overcome withdraws from highly addictive illicit substances, such as heroin, but it has detrimental oral health effects. This manuscript reviews the oral health manifestations of methadone maintenance therapy, and considers its implications to oral care. It hopes to raise awareness among health care professionals, regulating bodi...

The article is an animal study which addresses an important clinical issue i.e. hypogonadism and low testos-terone levels as a side effect of methadone and buprenor-phine (1). This is not an uncommon side effect which we see in patients receiving long term opioid maintenance treatment. Since methadone has been in use since the 1960s, clinicians became aware of this problem and it is usually add...

Methadone Maintenance Treatment (MMT) is among the most widely studied treatments for opiate dependence with proven benefits for patients and society. When misused, however, methadone can also be lethal. The issue of methadone diversion is a major concern for all MMT programs. A potential source for such diversion is from those MMT patients who receive daily take home methadone doses. Using a r...

Objectives: This study presents the comparative safety and side effect profiles of buprenorphine and methadone, including gender relationships, from a clinical trial comparing buprenorphine and methadone in the outpatient treatment of opioid dependence. Methods: One hundred sixty-four opioid dependent volunteers age 18–50 years were randomized to buprenorphine (n = 84) or to methadone (n = 80) ...

Many clients who undergo methadone maintenance (MM) treatment for heroin and other opiate dependence prefer abstinence from methadone. Attempts at methadone detoxification are often unsuccessful, however, due to distressing physical as well as psychological symptoms. Outcomes from a MM client who voluntarily participated in an Acceptance and Commitment Therapy (ACT) - based methadone detoxifica...

Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen-response element single nucleotide polymorphism (ERE-SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated...

In Australia, as in other comparable countries, the link between heroin addiction and acquisitive crime has been well documented. Around 40% of males incarcerated in Long Bay Gaol for property offences report having used heroin (Dobinson and Ward, 1985), indicating that heroin use is far more common in this group than in community samples, in which reported rates of ever having used heroin are ...