Hypophosphatasia (HPP) is a rare inborn error of metabolism due to a loss-of-function mutation in the gene for tissue nonspecific isoenzyme of alkaline phosphatase (ALP) that results in low levels of ALP. The clinical presentation of HPP is variable and in adults can easily be misdiagnosed as other forms of osteomalacia. We present a case of a 53-year-old Caucasian female who was evaluated for ...

Glycogen synthase kinase 3 (GSK3) inhibits signaling pathways that are essential for bone development. To study the requirement for GSK activity during endochondral bone development, we inhibited GSK3 in cultured metatarsal bones with pharmacological antagonists. Interestingly, we find that inhibition of GSK3 strongly repressed chondrocyte and perichondrial osteoblast differentiation. Moreover,...

Hallux valgus deformity is a very common pathological condition which commonly produces painful disability. It is characterised as a combined deformity with a malpositioning of the first metatarsophalangeal joint caused by a lateral deviation of the great toe and a medial deviation of the first metatarsal bone.Taking the patient's history and a thorough physical examination are important steps....

Analysis of the clinical cases (Figs. 1 to 27) suggested that the injuries could be classified into five types (Table I). This classification was confirmed by experiment (Figs. 28 to 40). A review of sixty radiographs previously published showed that all but three could be classified within this scheme. Cases 1 5 and 17 in the present series are not typical, but a reasonable approximation could...

OBJECTIVES To describe the radiographic appearance of the dorsoproximal aspect of the sagittal ridge of the third metacarpal/metatarsal bone in Warmblood horses. METHODS The lateromedial radiographic projections of the metacarpo-/metatarsophalangeal joints performed on horses as a part of stallion selection were used. The dorsal aspect of the distal third metacarpal/metatarsal bone was divide...

The suspensory ligament (SL) can be divided into three separate regions which are subject to injury: the proximal part, the body, and the branches. For clinical purposes in the forelimb the proximal part extends from approximately 4 to 12 cm distal to the accessory carpal bone, and in the hindlimb from approximately 2 to 10 cm distal to the tarsometatarsal joint. In the forelimb, the SL origina...

patient presentation A 22-year-old intoxicated male presented to the emergency department after jumping from a second-story window, landing on his right foot. He was able to ambulate with a great deal of pain across the dorsum of his foot. Physical examination revealed significant tenderness to palpation over the second metatarsal with minimal edema. Final diagnosis/relevant teaching points Rad...

The aim of this work was to use bone anchored external markers to describe the kinematics of the tibia, fibula, talus, calcaneus, navicular, cuboid, medial cuneiform, first and fifth metatarsals during gait. Data were collected from six subjects. There was motion at all the joints studied. Movement between the talus and the tibia showed the expected predominance of sagittal plane motion, but th...