The high global consumption of ibuprofen and its limited elimination by wastewater treatment plants (WWTPs), has led to the contamination aquatic systems this common analgesic metabolites. potentially negative environmental public health effects emerging contaminant have raised concerns, driving demand for technologies. implementation bacteria which mineralize organic contaminants in biopurific...

Background During cultivation cells undergo a tremendous change in their metabolism when shifting from one state to another or when parameters are changed. To understand the changes in intracellular metabolite concentrations and their impact on cell performance we used a systematic approach. By employing the chemostat mode at different steady state conditions we investigated the alterations of ...

fasting, that is usually described as abstinence from all food and drink for a period of time, has been experienced for ages. health, protest, religious expressions of devotion and purification are the most important reasons for fasting. many changes occur in the body during fasting including metabolic, mineral, hormonal, immunological and psychological. its use as one of the oldest therapies a...

Methanococcus maripaludis is a rapidly growing, fully sequenced, genetically tractable model organism among hydrogenotrophic methanogens. It has the ability to convert CO2 and H2 into a useful cleaner energy fuel (CH4). In fact, this conversion enhances in the presence of free nitrogen as the sole nitrogen source due to prolonged cell growth. Given the global importance of GHG emissions and cli...

In simple organisms like E.coli, the metabolic response to an external perturbation passes through a transient phase in which the activation of a number of latent pathways can guarantee survival at the expenses of growth. Growth is gradually recovered as the organism adapts to the new condition. This adaptation can be modeled as a process of repeated metabolic adjustments obtained through the r...

Microbial processes have been extensively used in engineered systems, esp. wastewater treatment, in situ bioremediation and most recently for biofuel production. While excess biomass may be desirable in some processes, it is detrimental to other systems including Activated Sludge Process (ASP), biofilters and subsurface bioremediation schemes, where uncontrolled microbial growth leads to increa...

Cobalt is essential for growth of Salmonella enterica and other organisms, yet this metal can be toxic when present in excess. Wild-type Salmonella exhibits several metabolic defects when grown in the presence of cobalt, some of which generate visible growth consequences. Work herein identifies sulfur assimilation, iron homeostasis, and Fe-S cluster metabolism as targets for cobalt toxicity. In...

Metabolic networks consist of linked functional components, or modules. The mechanism underlying metabolic network modularity is of great interest not only to researchers of basic science but also to those in fields of engineering. Previous studies have suggested a theoretical model, which proposes that a change in the evolutionary goal (system-specific purpose) increases network modularity, an...

In plants with Crassulacean acid metabolism, a diel separation of carboxylation processes mediated by phosphoenolpyruvate carboxylase (PEPC) and Rubisco optimizes photosynthetic performance and carbon gain in potentially limiting environments. This review considers the mechanisms that synchronize the supply and demand for carbon whilst maintaining photosynthetic plasticity over the 24 h CAM cyc...

A large number of studies have shown the existence of metabolic covalent modifications in different molecular structures, able to store biochemical information that is not encoded by the DNA. Some of these covalent mark patterns can be transmitted across generations (epigenetic changes). Recently, the emergence of Hopfield-like attractor dynamics has been observed in the self-organized enzymati...