Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sus...

In this study, we examine the relationship between the physical structure and dissolution behavior of olanzapine (OLZ) prepared via hot-melt extrusion in three polymers [polyvinylpyrrolidone (PVP) K30, polyvinylpyrrolidone-co-vinyl acetate (PVPVA) 6:4, and Soluplus® (SLP)]. In particular, we examine whether full amorphicity is necessary to achieve a favorable dissolution profile. Drug–polymer m...

The aim of the work reported herein was to implement process analytical technology (PAT) tools during hot melt extrusion (HME) in order to obtain a better understanding of the relationship between HME processing parameters and the extruded formulations. For the first time two in-line NIR probes (transmission and reflectance) have been coupled with HME to monitor the extrusion of the water insol...

The degradation of different polyethylenes, LDPE, LLDPE, and HDPE, with and without antioxidants and at different oxygen concentrations in the polymer granulates have been studied in extrusion coating processing. The degradation was followed by On Line Rheometry, Size Exclusion Chromatography, Surface Oxidation Index measurements, and GC-MS Chromatography. The degradations starts in the extrude...

In this work we report on the processing, melt-drawing, and performance of new vanillic acid based aliphatic-aromatic thermotropic polyesters. It is demonstrated that these materials are easily processed from their nematic melts yielding highly oriented products. Furthermore, we demonstrate that a molecular weight (Mw) of roughly 30 kg/mol is required in order to successfully perform spinning o...

This paper is concerned with the numerical solution of polymer melt flows of both extrudate-swell and tube-tooling die-extrusion coatings, using a hybrid finite element/finite volume discretisation fe/fv. Extrudate-swell presents a single dynamic freesurface, whilst the complex polymer melt coating flow exhibit two separate free-surface draw-down sections to model, an inner and outer conduit su...

the main objective of this study was to produce ldpe active films containing metallic nanoparticles (ag, zno and cuo) and to investigate their physical, mechanical and anti-microbial characteristics. three types of metallic nanoparticles at concentrations of 1% (w/w) were added to low density polyethylene (ldpe) and the films were prepared using melt extrusion technique. sem results indicated r...

• Raw lignin was modified through a green and scalable reactive extrusion design. Lignin/poly(butylene adipate-co-terephthalate) biomaterials were melt processed up to 90 wt% bio-content. Tough film blown shopping bags produced. Mechanical recycling composting verified as end-of-life options. Reactive design industrially scaled-up in conventional twin screw extruder.