Nitric oxide (NO) is a free radical and a signaling molecule in several pathways, produced by nitric oxide synthase (NOS) from the conversion of L-arginine to citrulline. Supplementation of L-arginine has been used to treat MELAS (mitochondrial encephalopathy with lactic acidosis and stroke like syndrome), a mitochondrial disease caused by the m.3243A>G mutation. Low levels of serum arginine an...

Quantization needs evaluation of all of states of a quantized object rather than its stationary states with respect to its energy. In this paper, we have investigated moduli Melas of a quantized elastica, a quantized loop with an energy functional associated with the Schwarz derivative, on a Riemann sphere P. Then it is proved that its moduli space is decomposed to a set of equivalent classes d...

BACKGROUND Myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome typically manifests in adults younger than 40 years with encephalopathy, stroke-like episodes, and lactic acidosis. Magnetic resonance imaging (MRI) abnormalities typically involve the cortical gray and the adjacent subcortical white matter. OBJECTIVE To describe a 58-year-old woman diagnosed with ...

There are some indications that seizure activity promotes the development of stroke-like episodes, or vice versa, in patients with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome or other syndromic mitochondrial disorders. A 41-year-old Caucasian female with MELAS syndrome, presenting with short stature, microcytic anaemia, increased blood-sedimentation r...

Presence of circumsporozoite protein (CSP) was Plasmodium falciparum detected by enzyme linked immunosorbent assay (ELISA) in a sample of s.s., and collected in Anopheles gambiae A. melas A. pharoensis Guinea-Bissau during October and November 2009. The percentage of P. infected samples (10.2% overall; confidence interval (CI): falciparum 7.45-13.6%) was comparable to earlier studies from other...

We herein report a rare case of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) and diabetes mellitus with ketoacidosis. An 18-year-old female patient was diagnosed to have diabetes mellitus and insulin therapy was thereafter initiated. At 26 years of age, she was hospitalized for diabetic ketoacidosis, soon followed by a loss of consciousness, left-side...

BACKGROUND Microangiopathy has been well described in the brain and muscle of patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). OBJECTIVE To describe a patient with the common A3243G/MELAS point mutation who had aortic rupture and whose mother also died of large vessel rupture. DESIGN Case report. SETTING Collaboration between a primary care ho...

The pathogenetic mechanism of the mitochondrial tRNA A3243G transition associated with the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome has been investigated in transmitochondrial cell lines constructed by transfer of mutant mitochondrial DNA (mtDNA)-carrying mitochondria from three genetically unrelated MELAS patients or of isogenic wild-ty...

Abstract We provide an alternative proof and expression of the Bellman function dyadic maximal operator in connection with Carleson imbedding theorem, which appears [A. D. Melas, The functions dyadic-like operators related inequalities, Adv. Math. 192 2005, 2, 310–340]. also evaluate four variables operator.

The segregation of mutant and wild-type mtDNA was investigated in transformants constructed by transferring human mitochondria from individuals belonging to four pedigrees with the MELAS encephalomyopathy-associated mtDNA mutation (MELAS is mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) into human mtDNA-less (rho 0) cells. Five of 13 clonal cell lines contain...