OBJECTIVE Exposure to sunlight in childhood is often more intense than in adults. Literature data unequivocally show the association between this social behavior and the risk for developing malignant melanoma and non-melanoma skin cancer, even in adulthood. Furthermore, skin photoaging begins already in childhood through inadequate sun exposure. This review aims to guide pediatricians on approp...

The report of differences between skin cancer rates and solid tumours in sunny versus less sunny countries [Tuohimaa P, Pukkala E, Scelo G, et al. Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: Vitamin D as a possible explanation. Eur J Cancer 2007; 43: 1701-12] raised some important questions regarding the roles of solar ultraviolet (UV) irradia...

AIMS To provide the first single-center study of a Czech renal transplant program that compares skin cancer risk estimates to the general population. METHODS We studied a total of 603 patients undergoing renal transplantation at the University Hospital Olomouc Transplant Center between January 1984 and December 2009. The mean time of follow-up was 5.5 years. Three patients were excluded for s...

Ultraviolet radiation (UVR) has been identified as the primary etiologic agent for the induction and promotion of most skin cancers. The first associations between solar UVR and skin cancer were acknowledged by the scientific community in 1927. Since then, increasing evidence for the role of UVR in the causation of skin cancer has resulted in the listing of solar and artificial UVR as a human c...

Skin cancer incidence has increased exponentially over the last three decades. In 2008 skin cancer caused 2280 deaths in the UK, with 2067 due to malignant melanoma. Early diagnosis can prevent mortality, however, conventional treatment requires multiple procedures and increasing treatment times. Second harmonic generation (SHG) imaging could offer diagnosis and demarcation of melanoma borders ...

Malignant melanoma is malignancy arising from the melanocytes of skin and mucous membrane. Melanocytes originated from neural crest from that they migrate during fetal growth to several organs and tissues, mostly to the skin. Malignant melanoma is most common skin cancer accounting for 78% of skin cancer related deaths (Bradford et al., 2009). The etiology of melanoma varies depending on locati...

Abstract: Skin cancer melanoma and non melanoma are common neoplasm with rising incidence over the last decades. It is an important public health problem. Its pathogenesis is not completely understood and the same happens with the genetic factors involved. The genes that encode the HLA are associated with some tumors and they may be responsible for one of the mechanisms that take part in the de...

BACKGROUND The endogenous antioxidant system of the skin scavenges reactive oxygen species and combats ultraviolet induced oxidative skin damage. Supporting this cutaneous defense system with topical or oral antioxidants may provide a successful strategy for the treatment and prevention of skin cancer. OBJECTIVE Review evidence regarding treatment and prevention of melanoma and nonmelanoma sk...

Cancer-associated fibroblasts (CAFs) play a key role in disease progression and treatment outcome. We used single-cell transcriptomics, CNV analysis, andin situ stainings to elucidate the yet unresolved intra-tumoral CAF heterogeneity melanoma non-melanoma skin cancer (basal squamous cell carcinoma, BCC SCC). identified three major subtypes, with their presence being indicative for tumor malign...