Since ages, the skin colour is an important issue for human race. Melanocyte abnormalities are mentioned during the fetal developmental stages in literature from ancient cultures. The deciding factor for the pigmentation is melanin. An old notion of melanocyte producing melanin is now obsolete. It is the epidermal unit which is responsible for the process of melanogenesis, production and distri...

Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin...

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine mela...

Vitiligo is an acquired chronic inflammatory skin disease culminating in depigmentation due to loss of epidermal melanocytes. Melanocyte homeostasis involves melanocyte stem cells, melanoblasts and differentiated interfollicular hair follicle melanocytes, which play important role repigmentation vitiligo. Our laboratory performed scRNAseq on cKit +ve human melanocytes purified by flow cytometry...

Melanocyte depletion occurs in vitiligo and aging associated hair greying (canities). Currently available therapies are unsatisfactory due to limited efficacy or therapy-related adverse effects. The purpose of our study is uncover previously unknown pathogenic pathways for canities develop that can block these pathways. Transcriptome sequencing-based immune cellular profiling was performed on s...