نتایج جستجو برای: medullary thymocytes
تعداد نتایج: 16527 فیلتر نتایج به سال:
Two-dimensional gel electrophoresis was used to detect [36S]methionine-labeled newly synthesized proteins from both glucocorticoid-sensitive and -resistant thymus cells. Normal thymic lymphocytes were taken for the sensitive population; the resistant population was composed of medullary thymocytes obtained from rats treated with dexamethasone (10 mg per kg body weight per day) for 3 days. When ...
Thymic epithelial cells (TECs) support T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection of developing thymocytes whereas medullary thymic epithelial cells (mTECs) facilitate the deletion of self-reactive thymocytes in order to prevent autoimmunity. The mTEC compartment is highly dynamic with continuous maturation and turnover, but the gene...
From murine medullary thymocytes we purified the receptor for the Amaranthus leucocarpus lectin (ALL) using a complex with the biotin-labeled lectin and avidin-agarose as the affinity matrix. Most ALL(+)thymocytes (83%) are naive cells with the CD4(+)CD8(-)CD45RB(+)phenotype. The receptor for this lectin is a 70 kDa glycoprotein that contains 20% of sugar by mass. It is constituted mainly by as...
To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1-100 microg of staphylococcal enterotoxin B (SEB) induced clonal elimination of SEB-reactive Vbeta8+ cells at the level of the semi-mature population of HSAhi CD4+ 8- cells...
سابقه و هدف: شکستگی درشت نی، یکی از شایعترین شکستگی های استخوان بلند در بدن است. درمان شکستگی های با زخم باز به صورت اولیه، همیشه موجب نگرانی جراحان بوده است. این مطالعه به منظور بررسی نتایج درمانی استفاده(flexible medullary nails, (fmn در بیماران با شکستگی با زخم باز درشت نی انجام شده است.مواد و روشها: این مطالعه توصیفی – تحلیلی بر روی 44 بیمار مبتلا به شکستگی با زخم باز ساق پا درمان شده به رو...
To investigate the influence of endogenous peptides on the developmental processes that occur during thymocyte selection, we have used monoclonal antibodies that preferentially recognize the major histocompatibility complex (MHC) molecule I-Ek when it is bound to the moth cytochrome c peptide (88-103). One of these antibodies (G35) specifically blocks the positive selection of transgenic thymoc...
The thymus provides a unique microenvironment enabling development and selection of T lymphocytes. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process by facilitating negative selection of self-reactive thymocytes and the generation of Foxp3(+) regulatory T cells. Although studies have highlighted the non-canonical nuclear factor κB (NF-κB) pathway as the key regulator...
Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus. The construct lacked a signal peptide and ECFP (enhanced cyan fluorescent protein) accumulated inside IL-7-producing stromal cells in tho...
Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of T cell maturation in the thymus of C57BL/6 mice. Sema7a was expressed at very...
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