BACKGROUND The addition of heated humidification to CPAP has been shown to improve nasal adverse effects in subjects with obstructive sleep apnea (OSA). However, current data regarding improvement in CPAP adherence is conflicting. Furthermore, there are no data from a tropical climate area with a high humidity level. METHODS In this prospective randomized crossover study conducted in Thailand...

BACKGROUND Mutations in centrosomal protein genes have been identified in a number of genetic diseases in brain development, including microcephaly. Centrosomal P4.1-associated protein (CPAP) is one of the causal genes implicated in primary microcephaly. We previously proposed that CPAP is essential for mother centriole maturation during mitosis. METHODS We immunostained CPAP-depleted cells u...

THE PRIMARY TREATMENT for obstructive sleep apnea (OSA) has been continuous positive airway pressure (CPAP) therapy, but the minimum acceptable number of hours of nightly CPAP use remains unclear. INTEGRATED SOFT TISSUE and bone surgery may be a viable alternative for patients who have rejected CPAP as a treatment option. Formal sleep testing has shown that surgery and CPAP therapy are equally ...

N asal continuous positive airway pressure (CPAP) is the primary treatment for symptomatic patients with obstructive sleep apnoeahypopnoea (OSAH). The best method for determining the optimal CPAP pressure is an ongoing subject of scrutiny. Both the American Academy of Sleep Medicine and the American Thoracic Society recommend supervised CPAP titration during overnight polysomnography, based on ...

BACKGROUND The sleep apnoea/hypopnoea syndrome (SAHS) is common and treatment with continuous positive airway pressure (CPAP) is effective. However, not all patients can cope with the demands of using mask positive pressure. Compliance can be improved with an intensive educational programme and patient support, but this is not practical in most centres given the large numbers of patients coming...

Background: Continuous positive airway pressure (CPAP) is the gold standard therapy for treating obstructive sleep apnea (OSA) disorder. However, patients’ adherence to its regular use is poor. The present study aimed to determine the adherence rate to CPAP therapy by identifying factors affecting its regular use and its associated problems and discomforts among a sample population in Mashhad (...

Abstract Introduction Sleep disturbance from obstructive sleep apnea (OSA) impairs overnight memory processing. This may be mediated by changes to slow wave (SWS) as less activity (SWA) is associated with worse spatial and declarative memory. We developed a within-subjects model of SWS-specific CPAP-withdrawal create 3 polysomnologically (PSG)-verified conditions 1) stable-SWS on CPAP, 2) SWS-f...

Numerous studies have demonstrated the efficacy of CPAP therapy for reducing symptoms (eg, daytime sleepiness), improving quality of life (QOL), reducing the risk of driving and occupational accidents, and preventing sequelae of obstructive sleep apnea (OSA), such as cardiovascular morbidity and mortality.1-3 Many patients have trouble complying with CPAP therapy even though it is effective.4 A...

BACKGROUND Adherence to short-term continuous positive airway pressure (CPAP) may predict long-term use. Unfortunately, initial CPAP intolerance may lead to poor adherence or abandonment of therapy. OBJECTIVE To determine whether a short course of eszopiclone at the onset of therapy improves long-term CPAP adherence more than placebo in adults with obstructive sleep apnea. DESIGN Parallel r...

BACKGROUND Rates of fresh gas flow (FGF) commonly used when continuous positive airway pressure (CPAP) is delivered by face mask theoretically reduce the delivery and availability of therapeutic aerosols. As it may be hazardous for patients with acute respiratory failure to interrupt mask CPAP, the effects of CPAP on aerosol kinetics and bronchodilator efficacy were investigated. METHOD The e...