Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician-administered invasive delivery methods, because non-invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceut...

1Metabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padova, Italy 2Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria 3Department of Diabetes and Metabolic Diseases, Livorno Hospital, 57100 Livorno, Italy 4Division of Obstetrics and Delivery Ward, Helen Schneid...

Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed t...

Chitosan has attracted much interest due to its special physical and chemical properties related to immunochemistry. The aim of this commentary is to appraise chitosan as an attractive functional polymer for medicine applications, which contributes to the development of chitosan for the immunochemistry. As reported, Chitosan has been used for immunochemistry purpose, such as functional food for...

In this article, applications of engineered nanoparticles containing siRNA for inhalation delivery are reviewed and discussed. Diseases with identified protein malfunctions may be mitigated through the use of well-designed siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics to the lungs for various pulmonary diseases. A siRNA delivery system ...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

objective: this study focused on the factors affecting the institutional delivery and delivery assisted by health professionals in urban slums. materials and methods: a semi-structured questionnaire was developed to collect information from women aged 15-49 who had at least one birth. totally 540 eligible women were interviewed. results: the results showed that around 20% of women delivered at ...

Nanotechnology is expected to have a revolutionary impact on biology and medicine. In this paper, I will discuss the role of nanotechnology in development of site-specific drug delivery systems. Polymeric nanoparticles, lipid nanosystems, and self-assembling nanosystems are described with special emphasis on targeted drug delivery in cancer therapy.

The discussion between general practitioners (GPs) and healthcare delivery organizations necessitates a common language. The presentation of the 4 types of GP’s activities, opens dialogue but can lead to possible misunderstandings between the micro- and macro-level of the healthcare system. This commentary takes 4 examples: costs reduction by P4, priority of beneficence or nonmaleficence, role ...

From *the Health Services Delivery Research Unit, Father Sean O’Sullivan Reserach Centre, St. Joseph’s Hospital, Hamilton, Ont.; the departments of †Family Medicine and ‡Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont.; §Digene Corporation, Silver Spring, Md.; ¶the Department of Pathology and Molecular Medicine, McMaster University; **the Department of Pathology, Uni...