The role of three major Ras downstream effector pathways in the induction of mammary cancer was studied using an in situ mammary ductal gene delivery model. Replication-defective retroviral vectors were used to infect endogenous rat mammary epithelial cells with three individual Ras effector loop mutants, each of which transduces its signal through a different Ras effector pathway (Raf, PI3K or...

E-RAS is a member of the RAS family specifically expressed in embryonic stem cells, gastric tumors, and hepatic stellate cells. Unlike classical RAS isoforms (H-, N-, and K-RAS4B), E-RAS has, in addition to striking and remarkable sequence deviations, an extended 38-amino acid-long unique N-terminal region with still unknown functions. We investigated the molecular mechanism of E-RAS regulation...

In the era of digital OT (Operating Theatre), developments in Robot-Assisted Surgery (RAS) can greatly benefit medical field. RAS is a method technological advancement that uses surgical robots to assist complicated surgeries. Its implementation improves ability specialised doctors perform surgery great extent. This paper addresses dynamics and control highly non-linear 3DOF robot manipulator o...

Despite the fact that there are wastewater treatment plants (WWTPs) currently operational across Iran and great advances have been made in this area, there are still problems in the design, construction, and operation of WWTPs with large nonlinear systems, varying flow rates, and pollution charges. The objective of this study was to investigate the effect of operating parameters including the r...

Regulation of non-classical renin-angiotensin system receptor gene expression in the adrenal 1 medulla by acute and repeated immobilization stress 2 Regina Nostramo, Lidia Serova, Marcela Laukova, Andrej Tillinger, Chandana Peddu, Esther L. Sabban 3 Department of Biochemistry and Molecular Biology 4 New York Medical College, Valhalla, NY 10595 5 6 7 Running Title: Stress and Non-classical RAS r...

Abstract :  Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  Cells expressing ac...

Since 2003 the radiologist assistant (RA) was introduced in response to the severe shortage of radiologists and the increased demand for medical imaging services. Other non-physician clinicians, such as PAs, currently play an important role in the medical imaging environment. The article discusses the reasons physician assistants have found favor with interventional radiologists, and advocates ...

1. Abstract 2. Introduction 2.1. Mutated proteins can induce malignant transformation 2.2. Mutant ras-p21 Protein Is a Major Cause of Cancer 2.3. ras-induced signal transduction pathways 2.4. Direct interactions between ras-p21 and target proteins depends largely on two of its domains 2.5. How amino acid substitutions in ras-p21 can induce it to become oncogenic 3. Methods 3.1. Computational me...