mediated dilation

Han Si Willm-Thomas Heyken Stephanie E. Wölfle Marcin Tysiac Rudolf Schubert Ivica Grgic Larisa Vilianovich Günter Giebing Tanja Maier Volkmar Gross Michael Bader Cor de Wit Joachim Hoyer Ralf Köhler

The endothelium plays a key role in the control of vascular tone and alteration in endothelial cell function contributes to several cardiovascular disease states. Endothelium-dependent dilation is mediated by NO, prostacyclin, and an endothelium-derived hyperpolarizing factor (EDHF). EDHF signaling is thought to be initiated by activation of endothelial Ca -activated K channels (KCa), leading t...

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