Improvements in child survival have contributed much of the gains in life expectancy at birth during the last two decades. At a global level, neonatal mortality has decreased from 36 to 19 deaths per 1000 livebirths between 1990 and 2012. However, the reduction in neonatal mortality between 1990 and 2015 (47%) has lagged behind that of postneonatal under-5 years mortality (58%) globally. The Ev...

Background: The appropriateness of using serum levels of procalcotonin (PCT) for early diagnosis of newborn sepsis is still controversial. Therefore, the objective of the present study was to compare the usefulness of PCT with those of serum levels of C-reactive protein (CRP) and white blood cell (WBC) counts in the diagnosis and response to treatment of neonatal sepsis. Methods: A total of 47 ...

Background and objective: Neonatal sepsis is defined as presence of clinical signs accompanied by positive blood culture in newborns less than one month of age. Sepsis is a common cause of hospital admission in neonates, and it is known as one of the main causes of mortality among them, not only in developed countries but in developing ones. Delay in diagnosis and appropriate antibiotic therapy...

neonatal bacterial sepsis is one of the major cause of morbidity and mortality in neonates. this retrospective study was performed to determine the incidence of bacterial sepsis with focus on gram negative organisms in neonates admitted at beheshti hospital in kashan, during a 3-yr period, from september 2002 to september 2005. blood culture was performed on all neonates with risk factors or si...

This study was conducted to find out the group B streptococcus colonisation of pregnant women in Kocaeli, Turkey. A culture plus individualised high-risk-based antibiotic prophylaxis was compared with high-risk-based approach alone. The screening of women was performed via vaginal and anal cultures for group B streptococcus (GBS). The maternal GBS colonisation rate was found to be 6.5%. All col...

OBJECTIVE To perform a decision analysis to understand better the implications of 19 potential group B streptococcus screening and treatment strategies. METHODS We searched the literature to locate appropriate articles from which to derive probability estimates. Using decision analysis, we determined the likely outcomes of 19 group B streptococcus screening and treatment strategies and focuse...

Background Procalcitonin is known as one of the bacteremia and sepsis markers such as cytokines, interleukin and reactive proteins. This study was conducted to determine the procalcitonin levels in neonatal sepsis. Materials and Methods In a cross-sectional study, the serum procalcitonin levels in 50 term newborns with suspected sepsis was compared with 50 healthy newborns in Ghaem Hospital, Ma...

BACKGROUND Neonatal sepsis is a severe clinical syndrome characterized by systemic signs of infection, shock and system organ failure; diagnosis is confirmed on positive culture from a normally sterile site(s). There are few reports comparing incidence, mortality, and risk factors between clinically diagnosed sepsis and that confirmed by culture. METHODS All infants diagnosed with early- (wit...

BACKGROUND Sepsis is one of the most common causes of neonatal hospital admissions and is estimated to cause 26% of all neonatal deaths worldwide. While waiting for results of blood culture, it is necessary to initiate an empirical choice of antibiotics based on the epidemiology of causative agents and antibiotic sensitivity pattern in a locality. OBJECTIVE To determine the major causative or...