Ion channels play a major role in the regulation of T cell function in health and disease. In a computer-based model, established to simulate T cells’ membrane potential (VM) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. The predicted VM was more hyperpolarized than the measured VM, indicating that a yet unknown, depolarizing ion current might ...

Previous optical imaging studies used the vector-summation (VS) method for calculating direction and orientation preference maps. However, for direction maps it often resulted in direction vectors which showed a steep angle to that of orientation vectors violating the 'aperture rule'. The present report provides a simple procedure for calculating direction preference maps using the 'electro- ph...

Green computing is the technological investigation where the system performance is optimized for achieving high performance computing in fewer amount of resource and power consumption. Therefore the presented work is an initiative for optimizing power consumption and performance enhancement by VM allocation and selection policies considering QoS expectations of the devices, which maximize the c...

Delta9-tetrahydrocannabinol (delta9-THC), the primary psychoactive constituent of marijuana, is subject to first pass hepatic metabolism primarily by hydroxylation to yield active and inactive oxygenated products. The primary metabolite is formed via oxidation of the allylic methyl group to yield 11-hydroxy-delta9-THC, which is oxidized further to 11-nor-9-carboxy-delta9-THC. The hydroxylation ...

Thermal diffusivities (a) and molar volumes (Vm) of bulk Al20AsxTe80Kx alloy glasses in the composition range 0%x%35 are examined. The results reveal a broad maximum in alpha and a broad minimum in Vm in the 15!x!25 range. Earlier temperature modulated differential scanning calorimetric measurements on these glasses have revealed the non-reversing heat flow to show a global minimum (reversibili...

Vasculogenic mimicry (VM) is a blood supply modality that is strongly associated with the epithelial-mesenchymal transition (EMT), TWIST1 activation and tumor progression. We previously reported that metastasis-associated in colon cancer-1 (MACC1) induced the EMT and was associated with a poor prognosis of patients with gastric cancer (GC), but it remains unknown whether MACC1 promotes VM and r...

Phenytoin dosing is often difficult in a clinical situation because of the non-linear nature of phenytoin metabolism at therapeutic plasma concentrations. This study was performed to examine retrospectively five pharmacokinetic methods of adjusting phenytoin dosage based on a single steady-state plasma phenytoin concentration-dose pair in 66 epileptic Chinese children and adults. The methods co...

Patellofemoral pain syndrome (PFPS) is one of the most common, yet misunderstood, knee pathologies. PFPS is thought to result from abnormal patella tracking caused from altered neuromuscular control. Researchers have investigated neuromuscular influences from the gluteus medius (GM), vastus medialis (VM), and vastus lateralis (VL) but with inconsistent findings. A reason for these discrepancies...