نتایج جستجو برای: matrix metalloproteinases

تعداد نتایج: 366071  

Journal: :Respiratory Research 2001
William C Parks Steven D Shapiro

Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and repair, among other events. Overexpression of MMPs, however, has also been blam...

Journal: :Journal of cell science 2004
Meng-Huee Lee Gillian Murphy

The matrix metalloproteinases (MMPs) are one of the major families of proteinases that play key roles in the responses of cells to their microenvironment. Most notably the MMPs have the combined capacity to degrade all the components of the extracellular matrix. Besides modulating tissue structure to facilitate remodeling, cell migration, etc. MMP activities can result in the generation of epit...

Journal: :Frontiers in bioscience : a journal and virtual library 2006
Peter S Burrage Kimberlee S Mix Constance E Brinckerhoff

The irreversible destruction of the cartilage, tendon, and bone that comprise synovial joints is the hallmark of both rheumatoid arthritis (RA) and osteoarthritis (OA). While cartilage is made up of proteoglycans and type II collagen, tendon and bone are composed primarily of type I collagen. RA is an autoimmune disease afflicting numerous joints throughout the body; in contrast, OA develops in...

Journal: :Biochemical Society transactions 2007
E Ganea M Trifan A C Laslo G Putina C Cristescu

MMPs (matrix metalloproteinases) are zinc-dependent endopeptidases that degrade both matrix and non-matrix proteins. They play an important role in morphogenesis, and in a wide range of processes including tissue repair and remodelling. Their abnormal expression contributes to pathological processes including arthritis, cancer, and cardiac and central nervous system diseases, which explains the...

Journal: :The European respiratory journal. Supplement 2003
W C Parks

The aims of this article are to discuss current concepts of the function of matrix metalloproteinases (MMPs), with an emphasis on identification of authentic substrates. Focusing on matrilysin (MMP-7), it is demonstrated how a single extracellular proteinase can regulate key and common functions of epithelial biology, namely defence against microorganisms , re-epithelialisation in response to i...

2006
Hahn Young Kim Seol-Heui Han

Matrix metalloproteinases (MMPs) are involved in the pathophysiology of several central nervous system diseases that share common pathogeneses, such as disruption of the blood-brain barrier (BBB), neuroinflammation, oxidative stress, and remodeling of the extracellular matrix (ECM). In early ischemic injury, MMPs participate in disruption of the BBB by digesting the basal lamina of capillaries ...

2002
Gillian Murphy Vera Knäuper Susan Atkinson George Butler William English Mike Hutton Jan Stracke Ian Clark

The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical stu...

Journal: :Journal of the American College of Cardiology 2004
Francisco Marín Vanessa Roldán Vicente Climent Gregory Y H Lip

We read with great interest the study by Boixel et al. (1), which examines the importance of matrix metalloproteinase (MMP) system in atrial remodeling in a rat model of heart failure. The investigators demonstrate the up-regulation of MMP-2 and MMP-9 in the atria with marked structural abnormalities, but there were no significant differences in tissue inhibitors of MMP (TIMP) activity. The cli...

Journal: :middle east journal of cancer 0
farshad naghshvar department of pathology, school of medicine, mazandaran university of medical sciences, sari, iran zhila torabizadeh gut and liver research center, mazandaran university of medical sciences, imam hospital, sari, iran jamshid yazdani charati department of biostatistics, school of public health, mazandaran university of medical sciences, sari, iran mohammad akbarnezhad department of pathology, school of medicine, mazandaran university of medical sciences, imam hospital, sari, iran

background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...

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