نتایج جستجو برای: matrix metalloproteinases
تعداد نتایج: 366071 فیلتر نتایج به سال:
Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and repair, among other events. Overexpression of MMPs, however, has also been blam...
The matrix metalloproteinases (MMPs) are one of the major families of proteinases that play key roles in the responses of cells to their microenvironment. Most notably the MMPs have the combined capacity to degrade all the components of the extracellular matrix. Besides modulating tissue structure to facilitate remodeling, cell migration, etc. MMP activities can result in the generation of epit...
The irreversible destruction of the cartilage, tendon, and bone that comprise synovial joints is the hallmark of both rheumatoid arthritis (RA) and osteoarthritis (OA). While cartilage is made up of proteoglycans and type II collagen, tendon and bone are composed primarily of type I collagen. RA is an autoimmune disease afflicting numerous joints throughout the body; in contrast, OA develops in...
MMPs (matrix metalloproteinases) are zinc-dependent endopeptidases that degrade both matrix and non-matrix proteins. They play an important role in morphogenesis, and in a wide range of processes including tissue repair and remodelling. Their abnormal expression contributes to pathological processes including arthritis, cancer, and cardiac and central nervous system diseases, which explains the...
The aims of this article are to discuss current concepts of the function of matrix metalloproteinases (MMPs), with an emphasis on identification of authentic substrates. Focusing on matrilysin (MMP-7), it is demonstrated how a single extracellular proteinase can regulate key and common functions of epithelial biology, namely defence against microorganisms , re-epithelialisation in response to i...
Matrix metalloproteinases (MMPs) are involved in the pathophysiology of several central nervous system diseases that share common pathogeneses, such as disruption of the blood-brain barrier (BBB), neuroinflammation, oxidative stress, and remodeling of the extracellular matrix (ECM). In early ischemic injury, MMPs participate in disruption of the BBB by digesting the basal lamina of capillaries ...
The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical stu...
We read with great interest the study by Boixel et al. (1), which examines the importance of matrix metalloproteinase (MMP) system in atrial remodeling in a rat model of heart failure. The investigators demonstrate the up-regulation of MMP-2 and MMP-9 in the atria with marked structural abnormalities, but there were no significant differences in tissue inhibitors of MMP (TIMP) activity. The cli...
background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...
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