Ye, Lin, and Taylor (2008, Biometrics 64, 1238-1246) proposed a joint model for longitudinal measurements and time-to-event data in which the longitudinal measurements are modeled with a semiparametric mixed model to allow for the complex patterns in longitudinal biomarker data. They proposed a two-stage regression calibration approach that is simpler to implement than a joint modeling approach...

Let E = ((eij))n×n be a fixed array of real numbers such that eij = eji, eii = 0 for 1 ≤ i, j ≤ n. Let the permutation group be denoted by Sn and the collection of involutions with no fixed points by Πn, that is, Πn = {π ∈ Sn : π = id, π(i) 6= i∀i} with id denoting the identity permutation. For π uniformly chosen from Πn, let YE = ∑n i=1 eiπ(i) and W = (YE − μE)/σE where μE = E(YE) and σ 2 E = ...

GC-MS-based metabolite profiling was used to analyse the response of Medicago truncatula cell cultures to elicitation with methyl jasmonate (MeJa), yeast elicitor (YE), or ultraviolet light (UV). Marked changes in the levels of primary metabolites, including several amino acids, organic acids, and carbohydrates, were observed following elicitation with MeJa. A similar, but attenuated response w...

r-Process nucleosynthesis in material ejected during neutron star mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients depend on the composition of the material after nuclear burning ceases, which determines the local heating rate from nuclear decays and the opacity. Kasen et al. (2013, ApJ, 774, 25) and Tanaka & Hotokezaka...

Toluene degradation in Pseudomonas putida KT2440 pWW0 plasmid is subjected to catabolite repression. Pu and P(S1) promoters of the pWW0 TOL plasmid are down-regulated in vivo during exponential growth in rich medium. In cells growing on minimal medium, yeast extract (YE) addition mimics exponential-phase rich medium repression of these promoters. We have constructed and tested mutants in a seri...

AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy (PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years (late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic a...