The aim of this study was to measure umbilical blood androgen concentrations in a birth cohort using a highly specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay and assesses the effects of sex, labor, and gestational age on fetal androgen levels at birth. We performed a prospective cohort study of androgen concentrations in mixed arterial and venous umbilical cord serum fr...

abstract background the aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. materials and methods this cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). growth assessment was measured by...

Background: The aim of this study is to analyze the correlation ovarian volume and clinical laboratory parameters polycystic ovary syndrome (PCOS) in Korean women. Methods: Two hundred thirty-three patients aged between 20 40 years with PCOS diagnosis January 2014 June 2020 at Pusan National University Hospital, Busan, Republic Korea, were included retrospective observational using previously r...

OBJECTIVE The objective of the present study was to investigate the effect of epipregnanolone on the influence of neurosteroids on the development of rapid tolerance to the motor impairing and hypothermic effects of ethanol. METHOD Experiment 1: on Day 1 groups of mice were pretreated with saline or with epipregnanolone. After 30 min each group was further divided in subgroups that received e...

background :reproductive endocrine disorders and sexual dysfunction are common among men with epilepsy. we investigated sexual hormone serum levels among men with newly diagnosed epilepsy, before starting any antiepileptic drug (aed), and then after starting carbamazepine (cbz), to determine the role and effects of epilepsy versus cbz in creating reproductive endocrine disorders.   methods : in...

The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine capacity of human platelets to produce sex steroid hormones. The DHEAS transport was evaluated through the uptake of [(3)H]-DHEAS in the presence or absence of different substrates through the organic anion transporting polypeptide (OATP) family. The activity of sulfatase enzyme was evaluated, and ...