Congenital CMV infection (cCMV) is the most common congenital infection causing permanent long-term impairments (LTI). cCMV immunopathogenesis is largely unknown due to the complex interplay between viral, maternal, placental, and child factors. In this study, a large retrospective nationwide cohort of children with cCMV and their mothers was used. HLA-C, HLA-E, and HLA-G were assessed in 96 mo...

Primary postpartum hemorrhage (PPH) plays a major role in maternal mortality and morbidity like severe anemia, blood transfusion requirement, hospital stay infection. Tranexamic acid is now recommended treatment of PPH, yet its prophylactic use before delivery still not recommended.

Declining levels of maternal antibodies were shown to sensitize infants born to dengue-immune mothers to severe disease during primary infection, through the process of antibody-dependent enhancement of infection (ADE). With the recent approval for human use of Sanofi-Pasteur's chimeric dengue vaccine CYD-TDV and several vaccine candidates in clinical development, the scenario of infants born t...

Placental invasiveness-the number of maternal tissue layers separating fetal tissues from maternal blood-is variable across mammalian species. Although this diversity is likely to be functionally important, variation in placental invasiveness remains unexplained. Here we test the hypothesis that increased risk of transplacental transmission of pathogens from the mother to the fetus promotes the...

BACKGROUND Neonatal infection is a serious public health problem. The aim of this study was to assess the influence of the antenatal care on the risk of early-onset neonatal healthcare associated infection in two Brazilian maternities. METHODS Cohort study - Newborns admitted at two public neonatal intensive care units from 2008 to 2009 were included in the study. Data on antenatal and perina...

For decades GBS has been the most common cause of early-onset neonatal infection. Ascending route infection with Group B Streptococcus bacteria increases risk preterm premature rupture membranes, fetus infection, sepsis, birth, and meningitis in infants. C-Reactive Protein is a sensitive marker systemic inflammation where an increase CRP can also be triggered by Objective this study to determin...

BACKGROUND The pathogenesis of malaria during pregnancy is not fully understood. A proinflammatory cytokine, macrophage migration inhibitory factor (MIF) is suggested as a factor involved in the pathogenesis of malaria during pregnancy. METHODS A cross-sectional study was conducted in Medani Hospital, Sudan to investigate MIF levels in placental malaria. Obstetrical and medical characteristic...

INTRODUCTION Young infants are protected from measles infection by maternal measles antibodies. The level of these antibodies at birth depends on the level of antibodies in the mother and the extent of placental transfer. We investigated predictors of levels of measles antibodies in newborns in rural Kenya. METHODS A total of 747 paired maternal-cord serum samples (91 from human immunodeficie...

Zika virus infection during pregnancy can cause congenital microcephaly and brain abnormalities (1), and detection of Zika virus RNA in clinical and tissue specimens can provide definitive laboratory evidence of recent Zika virus infection. Whereas duration of viremia is typically short, prolonged detection of Zika virus RNA in placental, fetal, and neonatal brain tissue has been reported and c...

Analysis of 1,317 patients admitted for N.H.S. abortion showed an overall morbidity of 16.8% excluding urinary tract infection. Genital infection, chest infection, reevacuation or perforation of the uterus, and haemorrhage were the more common complications. There was one maternal death.