نتایج جستجو برای: mast cell line

تعداد نتایج: 1974582  

2016
Ruoyu Wang Xiaoqin Yin Hui Zhang Jiwei Wang Lin Chen Jingwen Chen Xiaodong Han Zou Xiang Dongmei Li

Mast cells are traditionally considered as key effector cells in IgE-mediated allergic diseases. However, the roles of mast cells have also been implicated in diverse physiological and pathological processes. Mast cells are distributed in various organs and tissues of various species. Some of the organs and tissues, such as testis, skin, and the upper part of the respiratory tract, have a tempe...

2013
Joaquim Mullol Rosa Muñoz-Cano I Torres-Atencio E Ainsua M Martin J Sanchez-Lopez Joan Bartra Cesar Picado Antonio Valero

Background Platelet activating factor (PAF) is a lipid mediator that appears to be involved in the pathophysiology of several allergic reactions such as anaphylaxis and potentially urticaria and allergic rhinitis. The role of rupatadine, a drug with dual antihistamine and anti-PAF effect, in mast cell (MC) degranulation is not known. The objective of this study was to investigate the expression...

Journal: :Blood 1997
M F Gurish D S Friend M Webster N Ghildyal C F Nicodemus R L Stevens

Because in humans mast cells and basophils tend to possess nonsegmented and segmented/multi-lobular nuclei, respectively, nuclear morphology has been a major criterion for assessing the lineage of metachromatic cells of hematopoietic origin. Immature metachromatic cells with mono- and multi-lobular nuclei were both obtained when bone marrow cells from BALB/c mice were cultured for 3 weeks in th...

Journal: :The Journal of biological chemistry 1994
M M Dikov E B Springman S Yeola W E Serafin

By cDNA sequence analyses the proteases found within the secretory granules of immune/inflammatory cells appear to be translated initially as zymogens, but by amino-terminal sequencing they are stored within the granules in an active form. We now show that murine mast cell carboxypeptidase A (MC-CPA) is produced in a zymogen form (MC-pro-CPA) that is present at approximately 0.5% of the level o...

Journal: :International immunopharmacology 2015
Myoung-Schook Yoou Hyung-Min Kim Hyun-Ja Jeong

Acteoside (verbascoside) is extensively distributed in Abeliophyllum distichum and has antimicrobial and anti-inflammatory properties. Thymic stromal lymphopoietin (TSLP) has a pivotal function in the pathogeneses of inflammatory diseases through increasing the mast cell proliferation via the activation of murine double minute 2 (MDM2). Here, we investigate whether acteoside attenuates the MDM2...

Journal: :مجله علوم اعصاب شفای خاتم 0
leila alizadeh shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

mast cells are a heterogeneous population of granulocytic cells in the immune system. mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. in addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...

Journal: :iranian journal of pharmaceutical research 0
bardia jamali biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences, tehran, iran. maryam nakhjavani department of toxicology & pharmacology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran. leila hosseinzadeh toxicology and pharmacology department, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran. salimeh amidi department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. nastaran nikonezhad department of toxicology, sbmu pharmacy school, tehran, iran. farshad h. shirazi sbmu pharmaceutical sciences research center, p.o.box 14155-3817, tehran, iran.

one of the major complications in cancer chemotherapy is the development of resistance, and cisplatin, as one of the important medicines in treatment regimens of different cancers is not excluded. one of the most described cellular defense mechanisms involved in resistance is glutathione (gsh) and in this study, the effects of cisplatin on the total intracellular gsh level (gshi) in some sensit...

Journal: :International archives of allergy and immunology 2010
Sebastian Reuter Nina Dehzad Helen Martin Anke Heinz Timo Castor Stephan Sudowe Angelika B Reske-Kunz Michael Stassen Roland Buhl Christian Taube

BACKGROUND The migration of dendritic cells (DCs) from the lungs to the regional lymph nodes is necessary for the development of allergic airway disease. Following activation, mast cells release a variety of stored or de novo-produced inflammatory mediators, several of them being capable of activating DCs. In this study, the role of mast cells on DC migration from the lungs to the thoracic lymp...

Journal: :Journal of immunology 2009
Ramon J Mayoral Matthew E Pipkin Mikhail Pachkov Erik van Nimwegen Anjana Rao Silvia Monticelli

MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that have emerged as key posttranscriptional regulators in a wide variety of organisms. Because any one miRNA can potentially regulate expression of a distinct set of genes, differential miRNA expression can shape the repertoire of proteins that are actually expressed during development and differentiation or disease. Here, we...

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