Since its inception in 1898 the American Journal of Physiology has been a leader in diabetes research and has published many key articles on the subject. The Journal first published studies of phlorhizin-induced diabetes in 1898, and after many other contributions went on to publish the first reports of Banting, Best, Macleod, and Collip in 1922 concerning the isolation and purification of insu...

BACKGROUND Many studies have been conducted to evaluate the impact of quality improvement collaboratives (QICs) on the quality of healthcare. This article addresses an underexplored topic, namely the use of QICs as 'intentional spread strategy.' Its objective is to predict the dissemination of projects within hospitals participating in a change programme based on several QICs. We tested whether...

Organizational decision making often involves two decision levels. When the leader at the upper level attempts to optimize hislher objective, the follower at the lower level tries to find an optimized strategy according to each of possible decisions made by the leader. Furthermore, such bilevel decision making may involve uncertain parameters which appear either in the objective functions or co...

In previous work, our results suggested that some cities tend to be ahead of others in their musical preferences. We concluded that work by noting that to properly test this claim, we would try to exploit the leader-follower relationships that we identified to make predictions. Here we present the results of our predictive evaluation. We find that information on the past musical preferences in ...

Algorithms for solving Stackelberg games are used in an ever-growing variety of real-world domains. Previous work has extended this framework to allow the leader to commit not only to a distribution over actions, but also to a scheme for stochastically signaling information about these actions to the follower. This can result in higher utility for the leader. In this paper, we extend this metho...

Enterovirus (EV71) can cause severe neurological diseases, but the underlying pathogenesis remains unclear. The capsid protein, viral protein 1 (VP1), plays a critical role in the pathogenicity of EV71. High level expression and secretion of VP1 protein are necessary for structure, function and immunogenicity in its natural conformation. In our previous studies, 5 codon-optimized VP1 DNA vaccin...