Mantle cell lymphomas are uncommon subtypes of non-Hodgkin's lymphoma with poor overall survival ranging from 3-5 years. Patients are often middle aged men who would present with generalized lymphadenopathy and typical constitutional symptoms. Extranodal disease is typically found in the gastrointestinal tract, liver, spleen, and central nervous system. Lung involvement is typically restricted ...

Mutations and epigenetic alterations are key events in transforming normal cells to cancer cells. Mantle cell lymphoma (MCL), a non-Hodgkin's lymphoma of the B-cell, is an aggressive malignancy with poor prognosis especially for those patients who are resistant to the frontline drugs. There is a great need to describe the molecular basis and mechanism of drug resistance in MCL to develop new st...

The t(11;14)(q13;q32) translocation is considered to be the cytogenetic hallmark of mantle cell lymphoma. This report describes a case of leukaemic mantle cell lymphoma in which conventional cytogenetics on stimulated peripheral blood cells showed a 46,XY, t(1;12)(p21;q23)/46,XY karyotype. Fluorescence in situ hybridisation analysis using a dual colour immunoglobulin heavy chain (IgH)/CCND1 pro...