نتایج جستجو برای: mannoproteins

تعداد نتایج: 184  

2013
Alexander Striebeck David A. Robinson Alexander W. Schüttelkopf Daan M. F. van Aalten

The fungal cell possesses an essential carbohydrate cell wall. The outer layer, mannan, is formed by mannoproteins carrying highly mannosylated O- and N-linked glycans. Yeast mannan biosynthesis is initiated by a Golgi-located complex (M-Pol I) of two GT-62 mannosyltransferases, Mnn9p and Van1p, that are conserved in fungal pathogens. Saccharomyces cerevisiae and Candida albicans mnn9 knockouts...

Journal: :Journal of clinical pathology 2004
C Monteagudo A Viudes A Lazzell J P Martinez J L Lopez-Ribot

BACKGROUND The morphogenetic conversion between yeast and hyphal growth forms appears to be crucial in the pathogenesis of invasive candidiasis, and can be regulated by environmental signals such as extracellular pH. AIMS To characterise the epitope recognised by monoclonal antibody 1H4, and to evaluate the expression of its corresponding epitope in Candida albicans cells under different cond...

2014
Hiroki Okada Shinsuke Ohnuki Cesar Roncero James B. Konopka Yoshikazu Ohya

The cell wall of budding yeast is a rigid structure composed of multiple components. To thoroughly understand its involvement in morphogenesis, we used the image analysis software CalMorph to quantitatively analyze cell morphology after treatment with drugs that inhibit different processes during cell wall synthesis. Cells treated with cell wall-affecting drugs exhibited broader necks and incre...

Journal: :Biotechnology journal 2015
Arjan S Heeres Karin Schroën Joseph J Heijnen Luuk A M van der Wielen Maria C Cuellar

Developments in synthetic biology enabled the microbial production of long chain hydrocarbons, which can be used as advanced biofuels in aviation or transportation. Currently, these fuels are not economically competitive due to their production costs. The current process offers room for improvement: by utilizing lignocellulosic feedstock, increasing microbial yields, and using cheaper process t...

2011
Chirag C Sheth Rebecca Hall Leanne Lewis Alistair J P Brown Frank C Odds Lars P Erwig Neil A R Gow

The cell wall of the opportunistic human fungal pathogen, Candida albicans is a complex, layered network of rigid structural polysaccharides composed of β-glucans and chitin that is covered with a fibrillar matrix of highly glycosylated mannoproteins. Polymorphonuclear cells (PMNs, neutrophils) are the most prevalent circulating phagocytic leukocyte in peripheral blood and they are pivotal in t...

Journal: :Microbiology 2004
Sergej Sestak Ilja Hagen Widmar Tanner Sabine Strahl

Glycosyl hydrolases and transferases are crucial for the formation of a rigid but at the same time plastic cell wall in yeasts and fungi. The Saccharomyces cerevisiae glucan hydrolase family 17 (GH17) contains the soluble cell-wall proteins Scw4p, Scw10p, Scw11p and Bgl2p. For Bgl2p, endoglucanase/glucanosyltransferase activity has been demonstrated, and Scw11p has been shown to be involved in ...

Journal: :Revista iberoamericana de micologia 2012
Roberto Calcedo Andoni Ramirez-Garcia Ana Abad Aitor Rementeria José Pontón Fernando Luis Hernando

BACKGROUND Candida albicans is an opportunistic dimorphic fungus commonly present in the human oral cavity that causes infections in immunocompromised patients. The antigen variability, influenced by growth conditions, is a pathogenicity factor. AIMS To determine the effect of nutritional and heat stress on the antigen expression of C. albicans, and to identify major antigens recognized by hu...

Journal: :Frontiers in microbiology 2016
Beatriz Padilla José V. Gil Paloma Manzanares

It is well established that non-Saccharomyces wine yeasts, considered in the past as undesired or spoilage yeasts, can enhance the analytical composition, and aroma profile of the wine. The contribution of non-Saccharomyces yeasts, including the ability to secret enzymes and produce secondary metabolites, glycerol and ethanol, release of mannoproteins or contributions to color stability, is spe...

2013
Andoni Ramirez-Garcia Beatriz Arteta Ana Abad-Diaz-de-Cerio Aize Pellon Aitziber Antoran Joana Marquez Aitor Rementeria Fernando L. Hernando

The dimorphic fungus Candida albicans is able to trigger a cytokine-mediated pro-inflammatory response that increases tumor cell adhesion to hepatic endothelium and metastasis. To check the intraspecific differences in this effect, we used an in vitro murine model of hepatic response against C. albicans, which made clear that tumor cells adhered more to endothelium incubated with blastoconidia,...

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