UNLABELLED The antibiotic streptothricin (ST) possesses an amino sugar bound to an l-β-lysine (β-Lys) residue via a peptide bond. The peptide bond formation has been shown to be catalyzed by a nonribosomal peptide synthetase (NRPS) during ST biosynthesis. The focus of this study is the closely related ST analogue BD-12, which carries a glycine-derived side chain rather than a β-Lys residue. Her...

Laser forming is a modern process which is mainly used for forming metals. Different Lasers are used in this regard that includes Nd: YAG and CO2. In this study, forming bi-layer sheets of Aluminum/Ceramic by Laser was investigated. Furthermore, effect of Uniform and Gaussian heat flux distribution in different power, velocity, and beam diameters on bending angle was studied. FEM simulation ind...

Single point incremental sheet forming (SPISF) has demonstrated significant potential to form complex sheet metal parts without using component-specific tools and is suitable for fabricating low-volume functional sheet metal parts economically. In the SPIF process, a ball nose tool moves along a predefined tool path to form the sheet. This work aims to optimize the formability and forming force...

Significance The manipulation of proteins in a site-selective manner underpins much modern protein chemistry. A careful evaluation selenomethionine benzylation led to the identification highly efficient bromobenzyl linker for bioconjugation. This selenonium-forming ligation reaction can efficiently link other complex molecules such as synthetic peptides, polymers, or reactive handles. selenoniu...

The article is dedicated to one of the least explored in art history culture France phenomena XVI century – School Fontainebleau. Fontainebleau style stages formation analysis presented, First and Second Schools founders’ creative works main trends are described. nature with its dominant Italian traditions as manner foundation, leading northern influence analyzed. comparative was ca...

Background: Retinoic acid as one of the most important regulators for cell differentiation was examined in this study for differentiation of human umbilical mesenchymal cells (hUCM). Methods: After isolation, hUCM were evaluated for mesenchymal stem cell properties by flow cytometry and alkaline phosphatase assay. Also, doubling time of the cells and their differentiation potential into adipoge...

Present society of Iran, with its young population structure specially after forming and developing modernism and its conflict with tradition as well as the voluminous, various, rapid dominance of mass media has been affected by value conflict whether in micro level of personality or macro level of internalization and turned to a society full of conformance, adaptation, alienation, identity con...

Roll forming process is used for manufacturing sheet metal parts by successive bending and creating the final shape with gradual deformation. In this article, deformation of a pre-punched sheet due to the roll forming process was studied. Two main defects in the roll forming process are ovality of holes and bow defect. The ovality of the hole is influenced by the process parameters including sh...

in sheet metal forming processes, one-stage production of conical-cylindrical parts with high accuracy is very difficult due to wrinkling and rupturing. hydrodynamic deep drawing assisted by radial pressure is one of the most applicable procedures in sheet hydroforming process on the point of producing conical-cylindrical parts. in this paper, forming pressure path is investigated as one of the...