OBJECTIVE We examined the pulmonary toxicity of nickel oxide nanoparticle agglomerates in the rat lung following an intratracheal instillation. METHODS The weighted average surface primary diameter of nickel oxide nanoparticles was 8.41 nm, and the count median diameter of nickel oxide nanoparticle agglomerates suspended in saline was 1.34 µm. Male Wistar rats were exposed to 1 mg (3.3 mg/kg)...

Primary cultures of rat embryonic motor neurons deprived of brain-derived neurotrophic factor (BDNF) induce neuronal nitric oxide synthase (NOS) within 18 hr. Subsequently, >60% of the neurons undergo apoptosis between 18 and 24 hr after plating. Nitro-L-arginine and nitro-L-arginine methyl ester (L-NAME) prevented motor neuron death induced by trophic factor deprivation. Exogenous generation o...

It is well known that Li-ion cells containing manganese oxide-based positive electrodes and graphite-based negative electrodes suffer accelerated capacity fade, which has been attributed to the deposition of dissolved manganese on the graphite electrodes during electrochemical cell cycling. However, the reasons for the accelerated capacity fade are still unclear. This stems, in part, from confl...

Metal silicide nanowires (NWs) are very interesting materials with diverse physical properties. Among the silicides, manganese silicide nanostructures have attracted wide attention due to their several potential applications, including in microelectronics, optoelectronics, spintronics and thermoelectric devices. In this work, we exhibited the formation of pure manganese silicide and manganese s...

Forsterite (Mg2SiO4) powder was synthesized using magnesium and talc with assistance of ball milling. Manganese doped forsterite was prepared at weight percentage of 0.05%, 0.1%, 0.2%, 0.5% and 1.0wt% by adding manganese oxide before ball milling. The undoped and manganese doped forsterite were sintered at temperature of 1000°C, 1100°C and 1200°C. The Vickers hardness, fracture toughness and Yo...

Although silver nanowire meshes have already demonstrated sheet resistance and optical transmittance comparable to those of sputter-deposited indium tin oxide thin films, other critical issues including surface morphology, mechanical adhesion and flexibility have to be addressed before widely employing silver nanowire networks as transparent conductors in optoelectronic devices. Here, we demons...

In natural photosynthesis, the oxygen evolving center is a tetranuclear manganese cluster stabilized by amino acids, water molecules and counter ions. However, manganese complexes are rarely exhibiting catalytic activity in water oxidation conditions. This is also true for the family of water oxidation catalysts (WOCs) obtained from POM chemistry. We have studied the activity of the tetranuclea...

Many small-molecule anti-cancer drugs have short blood half-lives and toxicity issues due to non-specificity. Nanotechnology has shown great promise in addressing these issues. Here, we report the development of an anti-cancer drug gemcitabine-conjugated iron oxide nanoparticle for glioblastoma therapy. A glioblastoma targeting peptide, chlorotoxin, was attached after drug conjugation. The nano...

A simple method to obtain homogeneous sub-monolayer coverage of metal oxide and chalcogenide nanocrystals onto porous oxide supports is described. Quantitative nanoparticle coverage was probed using photonic macroporous oxide supports. Composites of nanocrystals of TiO₂, Fe₃O₄ or CdS dispersed onto macroporous SiO₂ or ZrO₂ all show a predictable linear shift in the photonic stop band position.