Background: Interests in natural products are being subjected to scientific method of testing. The use of Aloe Vera cuts across barriers of time and culture in the treatment of a broad range of illnesses. The basis of its reputation resides mainly with steadfast belief in claims of its curative properties, but without hard scientific evidence. Materials and Methods: Thirty three adult male rats...

objective(s): epilepsy is a neurodevelopmental disorder which is strongly influenced by genetic and environmental factors. gestational stress has been shown to be an important factor for affecting seizure susceptibility. the present study was conducted to address whether gestational stress may affect pentylentetrazol (ptz)-induced epileptic behavior in rat offspring in a sex- and age- dependent...

BACKGROUND Type 2 diabetes is associated with greater relative risk of cardiovascular diseases in women than in men, which is not well understood. Consequently, we have investigated if male and female displayed differences in cardiac function, energy metabolism, and endothelial function which could contribute to increased cardiovascular complications in type 2 diabetic female. METHODS Male an...

This review paper examines the relationship between chemicals inducing excessive accumulation of alpha 2u-globulin (alpha 2u-g) (CIGA) in hyaline droplets in male rat kidneys and the subsequent development of nephrotoxicity and renal tubule neoplasia in the male rat. This dose-responsive hyaline droplet accumulation distinguishes CIGA carcinogens from classical renal carcinogens. CIGA carcinoge...

Trichloroethylene (TRI) has been shown to cause a variety of tumors, particularly in mouse liver and lung and rat kidney. However, a clear association between exposure to TRI and cancer development in humans has not been established. Because TRI metabolism by cytochrome P450s has been implicated in the mechanisms of TRI-induced carcinogenicity in mice, the purpose of the present study was to ch...

During early ontogeny, stimuli that pose a threat to an animal change. Unrelated adult male rats may kill young rats, but infanticide ends around weaning. Predation, on the other hand, may increase during early ontogeny when rats begin to extend their activity range. We investigated the developmental course of two defensive responses, immobility and analgesia, in young rats exposed to an adult ...

Figure Legend: Figure 1 Bone Inflammation, Chronic in the bone of a male F344/N rat from a chronic study. Bone resorption is associated with inflammation. Figure 2 Bone Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study. Inflammatory cells surround a piece of bone that is undergoing resorption (sequestrum). Figure 3 Bone Inflammation, Chronic in a male F344/N rat from a chronic...

Dieta.—Male Wistar rats were placed on a semi synthetic diet at weaning, and the food consump tion of each was measured. A week later each rat was paired with one of equal body weight and food consumption. At this time one rat of each pair was designated as the experimental rat which would receive a tumor transplant; the other rat, his pair fed control, consumed the amount of diet eaten by th...

A specific and sensitive radioimmunoassay for rat carbonic anhydrase II (CAII) was developed. Rat livers were perfused with Ringer's solution and the hepatic CAII was measured. Concentrations of CAII in female liver were significantly higher than those in male liver. Castration increased the concentration in male liver, though not to that in females, and diethylstilboestrol treatment of castrat...

Role of sex differences on oxidative stress induced by benzene has been studied in liver, kidney and lungs of rat. It was observed that benzene administration enhanced lipid peroxidation in liver, kidney and lungs of rat, nevertheless, significant variations were recorded in male and female rats. Decrease of GSH and CYTP(450)2E1 was higher in female rats than male rats except lungs. The results...