S. A. HUBER,* J. E. STONE, D. H. WAGNER, JR., J. KUPPERMAN, L. PFEIFFER, C. DAVID, R. L. O’BRIEN, G. S. DAVIS, AND M. K. NEWELL Department of Pathology and Immunobiology Program and Pulmonary Disease and Critical Care Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405; National Jewish Medical Research Center, Denver, Colorado 80206, and Department...

Recent research has introduced the major histocompatibility complex class I (MHCI) genes as unexpected players in structural and synaptic plasticity in the central nervous system. In this issue of Neuron, Xu et al. redirect current theory by providing strong evidence for the inner retina as a site of action of MHCI proteins in retinogeniculate refinement.

Like its better-known polymorphic relatives, HLA-G, a relatively unpolymorphic class I MHC molecule expressed by fostal trophoblast cells, binds short peptides with a defined sequence motif; HLA-G may play an important role in maternal tolerance to a fostus.

background: major histocompatibility complex (mhc) in chicken has profound influence on resistance/susceptibility to disease, and production and reproduction traits. microsatellite marker lei0258 is a genetic indicator for mhc haplotypes. recognizing diversity of mhc haplotypes in selectively bred populations will be helpful for selecting population resistant to disease and development of effec...

Inhibitory receptors that engage self-MHC class I molecules enable NK cells to detect disease-associated loss of MHC class I on surrounding cells. Previous studies showed that some NK cells lack all receptors for self-MHC class I, yet fail to exhibit autoimmunity because they are generally hyporesponsive to stimulation. We asked whether NK cells exist in only two states, responsive and hyporesp...

The H-2dm1 mutation is unique among all described H-2 mutations in that two transplantation antigens, the H-2Dd and the H-2Ld, are affected. Here, we show that the mutant gene, Ddm1, is formed by fusion of the 5' part of the Dd gene and the 3' part of the Ld gene, with the region in between deleted. The recombination junction is located in the third exon, which encodes the alpha 2 region of the...

Male mouse urine contains a pregnancy-blocking chemosignal that causes pre-implantation pregnancy failure in recently mated female mice. However, females are able to recognize the chemosignal of the male with which they mated, preventing it from aborting his own offspring. The individuality of the pregnancy-blocking chemosignal is influenced by genes of the major histocompatibility complex (MHC...