Background There is evidence indicating impaired cardiomyocytic contractility, delayed electrical conduction and increased electrophysiological heterogeneities due to iron toxicity in beta-thalassemia major patients. In the present study, we compared the electrocardiographic and echocardiographic features of beta-thalassemia major patients with a healthy control group. Materials and Methods ...

This paper discusses an interesting result of Lata la [3] about the tail behaviour of Gaussian polynomials. I found it useful to present a new, more detailed version of Lata la’s rather concise proof by putting emphasis on its main ideas. I applied several ideas of the original work, but introduced some different arguments as well. I tried to explain the method of the proof by discussing the pi...

In 1993, as my freshman summer project, I wrote the first version of the Avida platform for digital evolution. This is an environment in which simple self-replicating computer programs evolve and adapt. Since 1993, the Avida platform has become a major model for investigating evolutionary principles. Of particular note, the BEACON NSF STC at MSU is partly centered around using Avida for researc...

Point and nonpoint sources of nutrients, sediments, metals, and organic compounds from industrial, agricultural, and urban land uses are important water-quality issues in the Study Unit. Degradation of streams, including the loss of riparian habitat, reduction in fish populations, loss of habitat for bottom-dwelling organisms, eutrophication, and deterioration of the sanitary quality of streams...

Zoonotic cutaneous leishmaniasis caused by Leishmania major is a most common type of vector-borne disease in Iran. The pentavalent antimonial drugs have been used in the treatment of cutaneous leishmaniasis for a long time, but drug resistance and some of serious side effects have been reported. Thus, discovery and development of new therapeutic candidates are needed. The CM11 peptide ...

Major life events have been found to precede onsets of a 1st lifetime episode of depression more commonly than subsequent recurrences. Despite general empirical support for this finding, few data directly address how the role of major life events may change over successive recurrences. Further, little research has examined major chronic difficulties in relation to a 1st lifetime episode versus ...

inroduction: heart failure (hf) is an important cause of morbidity and mortality in the cases of beta-thalassemia major. the purpose of this study was to estimate hf prevalence in these patients and to assess the survivability of those who were treated with intensive chelating therapy.   design and methods: this cross sectional study included 72 beta-thalassemia major cases, the mean age at the...

in leishmania (l.) major-infected balb/c mice th2-type cells results in disease progression, whereas c57bl/6-infected mice mount a th1-type response, which leads to control of the infection. th2 response correlates with igg1 whereas, th1 response supports switching to igg2a subclasses. since igg isotype-dominated response depends on different cd4 + t cell subsets, we studied the antigenic profi...