Svensson, M., 2000. Evolution of a Family of Plant Genes with Regulatory Functions in Development; Studies on Picea abies and Lycopodium annotinum. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 573. 45 pp. Uppsala. ISBN 91-554-4826-7. This work is focused on the molecular genetic basis for morphological change in evol...

We evaluated physical function, activity, and sleep status in five elderly individuals with musculoskeletal ambulatory disability symptom complex (MADS) for one year, examined their influential factors associated sarcopenia. Compared the baseline, results did not show significant differences every item. Notably, COVID-19 pandemic had occurred throughout Japan nearly entire study period. The imp...

The Arabidopsis FLOWERING LOCUS C (FLC) gene encodes a MADS box protein that acts as a dose-dependent repressor of flowering. Mutants and ecotypes with elevated expression of FLC are late flowering and vernalization responsive. In this study we describe an early flowering mutant in the C24 ecotype, flc expressor (flx), that has reduced expression of FLC. FLX encodes a protein of unknown functio...

Floral morphological novelties, like homeotic changes of whorl 1 organs, can easily arise by modifying existing regulatory networks. Ectopic expression of B-function MADS-box genes in whorl 1 leads to a replacement of sepals by petals, as is found in the Liliaceae. In cases where leaf-like sepals or even inflated calyces develop, which ultimately envelop the mature fruit as in Physalis, ectopic...

We investigate surrogate-assisted strategies for derivative-free optimization using the mesh adaptive direct search (MADS) blackbox optimization algorithm. In particular, we build an ensemble of surrogate models to be used within the search step of MADS, and examine different methods for selecting the best model for a given problem at hand. To do so, we introduce an order-based error tailored t...

Tomato plants harboring the ripening-inhibitor (rin) mutation yield fruits that fail to ripen. Additionally, rin plants display enlarged sepals and loss of inflorescence determinacy. Positional cloning of the rin locus revealed two tandem MADS-box genes (LeMADS-RIN and LeMADS-MC), whose expression patterns suggested roles in fruit ripening and sepal development, respectively. The rin mutation a...

The Mesh Adaptive Direct Search algorithm (MADS) is an iterative method for constrained blackbox optimization problems. One of the optional MADS features is a versatile search step in which quadratic models are built leading to a series of quadratically constrained quadratic subproblems. This work explores different algorithms that exploit the structure of the quadratic models: the first one ap...