Our aim was to assess the integrity of the photoreceptors in the fovea, and to measure the optical density of the macular pigment and the eye lens in patients with diabetes mellitus, and to compare the results with those of a group of healthy subjects. The directional and spectral properties of the light reflected from a 1.9 deg field centered on the fovea were measured simultaneously, in a sin...

Lutein and zeaxanthin are major carotenoids in the eye but are also found in post-receptoral visual pathways. It has been hypothesized that these pigments influence the processing of visual signals within and post-retina, and that increasing lutein and zeaxanthin levels within the visual system will lead to increased visual processing speeds. To test this, we measured macular pigment density (a...

AIM To evaluate the relationship between macular pigment optical density (MPOD) and glare disability in open-angle glaucoma. METHODS A cross-sectional analysis of baseline data (88 subjects; median age, 67 (range 36-84) years) collected during the Macular Pigment and Glaucoma Trial (ISRCTN registry number: 56985060). MPOD at 0.25°, 0.5° and 1° of retinal eccentricity was measured using custom...

CASE REPORT We present the clinical cases of two male patients of 38 and 39 years, diagnosed with Alport's syndrome, who suffered a bilateral macular hole and a giant unilateral macular hole with retinal thinning in the other eye, respectively. DISCUSSION Alport's syndrome is a genetic disorder characterised by mutation of genes encoding type IV collagen, the main component of the internal li...

Exudative retinal detachment occurs when fluid accumulates between the neurosensory retina and pigment epithelium. Ocular diseases or multisystem conditions such as nephrotic syndrome may lead to exudative detachment. This report describes a case of secondary minimal change disease, anasarca bilateral serous macular in an adult patient. A 75-year-old male patient presented emergency department ...

There is increasing recognition that the optical and antioxidant properties of the xanthophyll carotenoids lutein and zeaxanthin play an important role in maintaining the health and function of the human macula. In this review article, we assess the value of non-invasive quantification of macular pigment levels and distributions to identify individuals potentially at risk for visual disability ...

A 63-year-old female on long-term, high-dose tamoxifen treatment for metastatic breast cancer developed bilateral intraretinal refractile opacities, lesions at the level of the retinal pigment epithelium, and cystoid macular oedema.

True vitelliform dystrophy rarely appears in the adult population. We describe 10 cases in adults of bilateral vitelliform lesions clinically mistaken for Best's disease. Fluorescein angiography is a useful tool in distinguishing this dystrophy from Best's disease or other diseases. The angiographic findings suggest pigment epithelial disease. Adult vitelliform degeneration may lead to dry atro...

PURPOSE To report the optical coherence tomography (OCT) findings in a patient with unilateral macular coloboma. METHODS A 12-year-old male was presented with macular coloboma in the left eye. The optical coherence tomography was performed with fluorescein angiography (FA). RESULTS The OCT revealed the crater-like depression in the macula, demonstrating atrophic neurosensory retina, and an ...