OBJECTIVES To evaluate therapy for Mycoplasma genitalium infection with doxycycline or azithromycin 1 g compared to five days of azithromycin (total dose 1.5 g). METHODS A retrospective case study was performed among patients attending the STD-clinic in Falun, Sweden 1998-2005. All patients with a positive PCR test for M. genitalium were routinely offered a test of cure (toc). Response to dox...

The current study intends to characterize the respiratory tract infections that have an association with gram positive bacterial pathogens, emm typing, pattern of antibacterial resistance in isolated phenotyping virulence factor and molecular detection Macrolide gene. Various samples from patients were collected identification antimicrobial susceptibility clinical isolates was performed as per ...

Macrolide-resistant Mycoplasma pneumoniae plays an important role in refractory M. pneumoniae pneumonia. Here, we present the whole-genome sequencing of the macrolide-resistant M. pneumoniae strain S355. The annotated full-genome sequence might provide a new insight into drug resistance in M. pneumoniae and can help pediatricians recognize the disease earlier.

As part of their interesting review of long-term macrolide therapy in chronic inflammatory airway diseases, CROSBIE and WOODHEAD [1] cite eight randomised double-blind placebocontrolled trials of macrolide therapy in asthma. Most were small, and all were short-term (none .12 weeks). Some positive effects were noted; mechanisms proffered included both anti-inflammatory and antimicrobial (includi...

Sir: Several publications report psychiatric symptoms induced by macrolide antibiotics. Clarithromycin and erythromycin used in combination with other treatments, or even in monotherapy, have been reported to produce acute psychoses, manic episodes, and depression. To our knowledge, this is the first report of an association between azithromycin, another macrolide antibiotic, and the initiation...

A 2.7% prevalence of macrolide resistance in 1,657 Norwegian clinical Streptococcus pyogenes isolates was primarily due to erm(TR) (59%) and mef(A) (20%). Four clonal complexes comprised 75% of the strains. Macrolide resistance in S. pyogenes in Norway is imported as resistant strains or locally selected in internationally disseminated susceptible clones.

Macrolides are an important tool in the treatment of Mycobacterium avium complex infections. Here, we evaluate the use of 23S rRNA gene sequencing for the rapid detection of macrolide resistance. Routine sequencing of the 23S rRNA gene is highly specific for macrolide resistance but lacks in sensitivity.

Macrolide resistance in Mycoplasma pneumoniae is often found in Asia but is rare elsewhere. We report the emergence of macrolide-resistant M. pneumoniae in Israel and the in vivo evolution of such resistance during the treatment of a 6-year-old boy with pneumonia.