The circumstellar material surrounding most low-mass young stars in the Orion Nebula Cluster is rendered visible by the ionizing radiation of the hot Trapezium stars and the background light of M42. I discuss Hubble Space Telescope observations of these lower mass young stellar objects and their environments. Photoionization of circumstellar material by 1Ori C produces a bright cusp-shaped ioni...

Abstract Background Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. The long-term, Phase 3b/4 RIVETING study (NCT03281304) assessed efficacy and safety tofacitinib dose reduction from 10 mg twice daily (BID) maintenance therapy to 5 BID in patients (pts) stable remission.1 We present a final analysis after ≥30 months treatment. Methods was d...

BACKGROUND/AIM A study of morphological lesions in the liver of heroin addicts enables a precise overview of the type and degree of the liver damages caused by intravenous (i.v.) heroin abuse, additive effects of viral infections and alcohol consumption, as well as whether the expressiveness of these lesions depends on the duration of the time period of heroin application. The aim of the study ...

A newly developed assay system which uses actinomycin D (Act D) pretreated Wehi 164 target cells allows for the measurement of human monocyte cytotoxicity in a 7-h 51Cr release assay. Using the monocyte specific monoclonal antibody M42 in a direct rosetting procedure we confirm herein that among human peripheral blood mononuclear cells cytotoxicity is restricted to monocytes. When applying stri...

__________________________________________________________________________________ Abstract. Apart from the usual morphological changes in the liver of intravenous heroin users such as vesicular and fatty changes, various forms of viral hepatitis and development of cirrhosis, the onset of amyloidosis, the change in the number of hepatic sinusoidal macrophages, and dysplastic changes are of part...