Metallothionein (MT) promoter was methylated in rat hepatoma and in mouse lymphosarcoma cells by methylation of cytosine within the CpG dinucleotide region. After demethylation of MT-I promoter in mouse lymphosarcoma cells or in the transplanted rat hepatoma with 5-azacytidine, a potent inhibitor of DNA methyltransferase, the promoter was activated in response to heavy metal treatment. MT-I pro...

This case report describes the late development of an achalasia-like disturbance of oesophageal motility following irradiation to the neck for a pharyngeal lymphosarcoma. The radiological, manometric and endoscopic findings are recorded as well as laboratory investigations showing evidence of complete vagal denervation.

Thirteen cases of lymphoma of the bowel in infancy and childhood are presented. There is a marked preponderance in males. The tumour most commonly presents with abdominal pain and intestinal obstruction; the prognosis is poor. Histological findings characteristic of the ;Burkitt' type of lymphosarcoma do not apparently influence survival.

Ovine lymphosarcoma was diagnosed clinically in a 5-year-old Blackhead sheep in Kenya, and confirmed on blood smear, leukocyte count and macroscopic pathology. Four progeny of the ewe were examined. They were normal haematologically but 2 revealed bilaterally enlarged lymph nodes.

A case is reported of a 32 year old woman with a two year history suggestive of schizophrenia who presented in stupor. This proved to be due to hypercalcaemia with a concomitant high cerebrospinal fluid calcium concentration associated with previously unsuspected lymphosarcoma. Necropsy revealed no significant intracranial abnormality, and mechanisms that may have been involved in the productio...

lowed by determination of radioactivity in respiratory COj, protein, lipids, organic acids, and free amino acids. The greatest quantitative and qualitative changes in asparagine metabolism were found in lymphosarcoma with leukemic blood picture. Chronic lymphocytic leukemia resembled the normal pattern with acute lymphocytic leukemia occupying an intermediate position. With pro gression of chro...

Different preparations obtained from cultures of Serratia marcescens and Strepto coccus pyogenes were tested in seven spontaneous, induced, and transplanted tumors of mice, and Rous sarcoma in chicks. The toxins were found to be effective against Krebs-2 carcinoma causing regression of well established tumors. They were found to be ineffective against Sarcoma 180, Gardner's Lymphosarcoma 6C3HED...