The kinetics of cellular commitment in the stimulation of lymphocytes by concanavalin A (Con A) has been analyzed by measurement of DNA synthesis, autoradiography, and histologic staining techniques. If the competitive inhibitor alpha-methyl-D-mannoside (alphaMM) is introduced into cultures of mouse spleen cells at various times after the addition of Con A, there is a gradual decrease in its ca...

The influence of herpes zoster virus infection on cell-mediated and humoral immunity to varicella-zoster virus (VZV), cytomegalovirus, and herpes simplex virus (HSV) was followed in 17 zoster patients from the first week to 6 months after start of eruptions. The clinical responses were registered and correlated to the immune responses. A significant depression in blast transformation on stimula...

A model for cell kinetics of human acute lymphoblastic leukemia has been constructed with discrete modeling techniques for computer use with the GPSS/360 computer Ianguage.The model has produced results corresponding to observed biological data. It has been possible to explore mechanisms for control of the growth of the leukemic cell population. In addition to the flow of cells from the resting...

Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformat...

T HERE HAS BEEN increasing acceptance of the concept that small lymphocytes can transform both in vitro and in vivo into larger cells capable of division.19 Repeated observation have shown that an increase in basophilic cytoplasm is an essential aspect of this transformation. Furthermore, electron microscopic studies of small lymphocytes growing in tissue culture have shown increase in ribosoma...

A study was made of PHA-stimulated formation is age-related. Until the 18th thymic lymphocyte transformation in 10 week of gestation, the per cent of transhuman fetuses ranging from 12 to 22 formed thymic lymphocytes is comparaweeks of gestation. The results were ble to that of blood lymphocytes. After compared with those obtained using cirthe 18th week of gestation, the per cent culating blood...

A study was made of PHA-stimulated formation is age-related. Until the 18th thymic lymphocyte transformation in 10 week of gestation, the per cent of transhuman fetuses ranging from 12 to 22 formed thymic lymphocytes is comparaweeks of gestation. The results were ble to that of blood lymphocytes. After compared with those obtained using cirthe 18th week of gestation, the per cent culating blood...

A study was made of PHA-stimulated formation is age-related. Until the 18th thymic lymphocyte transformation in 10 week of gestation, the per cent of transhuman fetuses ranging from 12 to 22 formed thymic lymphocytes is comparaweeks of gestation. The results were ble to that of blood lymphocytes. After compared with those obtained using cirthe 18th week of gestation, the per cent culating blood...

A study was made of PHA-stimulated formation is age-related. Until the 18th thymic lymphocyte transformation in 10 week of gestation, the per cent of transhuman fetuses ranging from 12 to 22 formed thymic lymphocytes is comparaweeks of gestation. The results were ble to that of blood lymphocytes. After compared with those obtained using cirthe 18th week of gestation, the per cent culating blood...

A study was made of PHA-stimulated formation is age-related. Until the 18th thymic lymphocyte transformation in 10 week of gestation, the per cent of transhuman fetuses ranging from 12 to 22 formed thymic lymphocytes is comparaweeks of gestation. The results were ble to that of blood lymphocytes. After compared with those obtained using cirthe 18th week of gestation, the per cent culating blood...