Murine monoclonal antibody (mAb) Lym-1 is an immunoglobulin G2a specific for certain human leukocyte antigen-DR variants expressed on the surface of malignant B cells. It has been proposed for serotherapy in patients with B lymphomas. We have previously shown that mAb Lym-1 synergizes with granulocyte macrophage-colony stimulating factor to promote Raji B-lymphoid cell lysis by human neutrophil...

Murine monoclonal antibody (mAb) Lym-1 is an immunoglobulin G2a specific for certain human leukocyte antigen-DR variants expressed on the surface of malignant B cells. It has been proposed for serotherapy in patients with B lymphomas. We have previously shown that mAb Lym-1 synergizes with granulocyte macrophagecolony stimulating factor to promote Raji B-lymphoid cell lysis by human neutrophils...

Promising results from clinical trials have led to renewed interest in effector mechanisms operating in antibody-based therapy of leukemia and lymphoma. We tested a panel of B-cell antibodies from the Sixth Human Leukocyte Differentiation Antigen workshop for their capacity to mediate antibody-dependent cellular cytotoxicity, often considered to be one of the most potent effector mechanisms in ...

in A l>sreactive with epitopes expressed on tumor vessels were evaluated as universal delivery agents of peptides with vasoactive properties to enhance the uptake of macromolecules in tumors. Unlike other reported approaches to target tumor vessels, a mAb designated TV-1 targets a basement membrane antigen that is found in all tissues but that is acces sible only in tumor vessels, making it an ...

While much is known about the influence of the estrogens, androgens, and adrenocortical hor mones on experimental leukemia, very little has been published on the effect of the thyroid gland on this disease. However, it has been assumed that the thyroid might play a role in leukemia, inas much as lymphocytosis is frequently observed in hyperthyroid subjects; moreover, growth of lym phatic tissue...

BACKGROUND Epidemics of HFMD are elevated every year globally, especially in mainland China. The disease now presents as an increasing threat to public health worldwide. METHODS Five hundred and seventy-one EV71-infected HFMD patients in Beijing You'an Hospital were grouped by disease severity: Mild (no severe complication) (n=221), and Severe group (complicated with brainstem encephalitis (B...

The aim of the present study was to investigate and show the differences in blood parameters related with age and sex of Žemaitukai horse breed in Lithuania. According to the blood parameters, they may be assigned to a particular blood type. Haematological parameters [(red blood cells (RBC), white blood cells (WBC), hemoglobin concentration (Hb), hematocrit (HCT), lymphocytes (LYM), platelet (P...

Despite their large size, antibodies have proven to be suitable radioisotope carriers to deliver systemic radiotherapy, often molecular image-based, for lymphoma and leukemia. To mimic antibody (Ab) targeting behavior while decreasing size by 50-100x, a combination of computational and experimental methods were used to generate molecules that bind to unique sites within the HLA-DR epitopic regi...