Prognosis of metastatic breast cancer is very poor which urges the necessity to develop novel potential drug candidates. We assessed two compounds with tri-aryl structures (A and B) for their potency to reduce primary breast tumor growth and lung metastasis in 4T1 mice model. MTT assay, 4T1 mammary mouse model and immunohistochemistry experiments were used in this study. In vitro results exhibi...

Background: Breast conserving surgery (BCS) followed by radiotherapy (RT) has been widely accepted as the standard treatment in early stages of invasive breast cancer. The standard technique of RT includes whole breast irradiation (WBI). Additional tumor bed boost irradiation has also an important role in the local tumor control. But there are various controversial delivery methods. The aim of ...

BACKGROUND Large tumor motion often leads to larger treatment volumes, especially the lung tumor located in lower lobe and adhered to chest wall or diaphragm. The purpose of this work is to investigate the impacts of planning target volume (PTV) margin on Stereotactic Body Radiotherapy (SBRT) in non-small cell lung cancer (NSCLC). METHODS Subjects include 20 patients with the lung tumor locat...

PURPOSE Volumetric modulated arc therapy (RapidArc; Varian Medical Systems, Palo Alto, CA) allows fast delivery of stereotactic radiotherapy for Stage I lung tumors. We investigated discrepancies between the calculated and delivered dose distributions, as well as the dosimetric impact of leaf interplay with breathing-induced tumor motion. METHODS AND MATERIALS In 20 consecutive patients with ...

PURPOSE To develop a neural-network based autocontouring algorithm for intrafractional lung-tumor tracking using Linac-MR and evaluate its performance with phantom and in-vivo MR images. METHODS An autocontouring algorithm was developed to determine both the shape and position of a lung tumor from each intrafractional MR image. A pulse-coupled neural network was implemented in the algorithm f...

Solitary fibrous tumor (SFT) is a rare mesen­chymal tumor of the pleura, which arises from visceral pleura and projects into the pleural cavity. This tumor is not related to asbestos exposure or cigarette smoking (1). We report a rare case of SFT of the lung. In this case report, we present the case of a giant SFT in a 76-year-old woman who presented with the complaint of chest pain on the left...

Despite the well-known benefits of positron emission tomography (PET) imaging in lung cancer diagnosis and staging, the poor spatial resolution of PET has limited its use in radiotherapy planning. Methods used for segmenting tumor from normal tissue, such as threshold boundaries using a fraction of the standardized uptake value (SUV), are subject to uncertainties. The issue of respiratory motio...

Objective(s): Lung cancer is one of the most common malignant tumors, which seriously threatens the health and life of the people. Recently, a novel long non-coding RNA (lncRNA) termed lncFOXO1 was found and investigated in breast cancer. However, the effect of lncFOXO1 on lung cancer is still ambiguous. The current study aimed to uncover the functions of lncFOXO1 in l...