BACKGROUND Lung transplantation is a well-established therapeutic option for end-stage lung disease in cystic fibrosis. Although it confers a clear survival advantage, outcome differs among centers according to local experience, patient selection, transplantation procedure, and postoperative care. OBJECTIVES To evaluate the national Israeli experience with lung transplantation in patients wit...

ackground: Previous studies have shown that mucociliary clearance (MCC) is diminished after lung transplantation. However, it is unknown how early this deficit occurs after transplantation, or whether the abnormality can be improved by pharmacologic means. We hypothesized that impairment of MCC is evident soon after lung transplantation and that the defect in MCC can be improved by inhaled 2-ad...

BACKGROUND The use of donation-after-circulatory-death (DCD) donors for lung transplantation has come into practice. In this study we investigated whether DCD lungs can be resuscitated after warm ischemia with normothermic ex vivo lung perfusion (EVLP). METHODS Four hours after cardiac arrest, beagle dogs were divided into two groups (n = 6 each): those with static cold storage (SCS group) an...

Background. Although certain forms of end-stage lung disease are debilitating, whether the associated mortality rate exceeds that of transplantation is unclear. We undertook analysis to clarify the surviva benefit of lung transplantation for various types of end-stage lung disease. Methods. We analysed data for all patients listed for transplantation in the USA for emphysema, cystic fibrosis, o...

BACKGROUND Lung transplantation is an important option to treat patients with advanced cystic fibrosis (CF) lung disease. The outcomes of a large UK cohort of CF lung transplantation recipients is reported. METHODS Retrospective review of case notes and transplantation databases. RESULTS 176 patients with CF underwent lung transplantation at our centre. The majority (168) had bilateral sequ...

Ventilator-dependent patients are considered poor candidates for lung transplantation. A 17 year old boy developed adult respiratory distress syndrome (ARDS) due to paraquat poisoning. A single lung transplantation was carried out with a successful outcome. (Thorax 1998;53:620–621)

We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectious pulmonary complications. Among 174 patients undergoing transplantation for hematologic malignancies between May 1994 and December 2004, 81 long-term survivors were evaluated. Pulm...

CONTEXT Patients with cystic fibrosis (CF) are the second largest group of lung transplant recipients in the United States. The survival effect of transplantation on a general CF population has not previously been measured. OBJECTIVE To determine the impact of bilateral lung transplantation on survival in patients with CF. DESIGN, SETTING, AND PATIENTS Retrospective observational cohort stu...

Ventilator-dependent patients are considered poor candidates for lung transplantation. A 17 year old boy developed adult respiratory distress syndrome (ARDS) due to paraquat poisoning. A single lung transplantation was carried out with a successful outcome.