BACKGROUND The accuracy of dose calculation is crucial to the quality of treatment planning and, consequently, to the dose delivered to patients undergoing radiation therapy. Current general calculation algorithms such as Pencil Beam Convolution (PBC) and Collapsed Cone Convolution (CCC) have shortcomings in regard to severe inhomogeneities, particularly in those regions where charged particle ...

Background: This study aimed to evaluate the dose calculation accuracy of EclipseTM treatment planning system (TPS) in a heterogeneous chest phantom with the intensity modulated radiotherapy (IMRT) technique using EBT3 film and Delta4. Materials and Methods: Two IMRT plans (A and B) were prepared for radiotherapy of the heterogeneous chest phantom. Plan A was between the left lung and the surro...

PURPOSE Volumetric modulated arc therapy (VMAT) is a specific type of intensity-modulated radiation therapy (IMRT) in which the gantry speed, multileaf collimator (MLC) leaf position, and dose rate vary continuously during delivery. A treatment planning system for VMAT is presented. METHODS Arc control points are created uniformly throughout one or more arcs. An iterative least-squares algori...

PURPOSE To survey image guided radiation therapy (IGRT) practice patterns, as well as IGRT's impact on clinical workflow and planning treatment volumes (PTVs). METHODS AND MATERIALS A sample of 5979 treatment site-specific surveys was e-mailed to the membership of the American Society for Radiation Oncology (ASTRO), with questions pertaining to IGRT modality/frequency, PTV expansions, method ...

Background: Radiation-induced cardiac events and pneumonitis are the major late radiotherapy side effects. Methods: We explored differences in dose distribution between 3D CRT, IMRT VMAT 125 women with unilateral breast cancer. The various to tumor OARs were studied for left right sided irradiation. Results: Upon using CRT breasts lymph nodes, we observed a significant increase ipsilateral lung...

The aim of this study was to investigate the association between absolute volumes of lung spared from low-dose irradiation and radiation-induced lung injury (RILI) after intensity-modulated radiotherapy (IMRT) for lung cancer. The normal lung relative volumes receiving greater than 5, 10, 20 and 30 Gy (V5-30) mean lung dose (MLD), and absolute volumes spared from greater than 5, 10, 20 and 30 G...

AimsSkin toxicity is a common adverse effect of breast radiotherapy. We investigated whether inverse-planned intensity-modulated radiotherapy (IMRT) would reduce the incidence skin compared with forward field-in-field IMRT (FiF-IMRT) in early stage cancer.Materials and methodsThis phase III randomised controlled trial whole-breast irradiation either FiF-IMRT or helical tomotherapy (HT-IMRT), as...

OBJECTIVE To compare the radiobiological response between simultaneously dose-escalated and non-escalated intensity-modulated radiation therapy (DE-IMRT and NE-IMRT) for patients with upper thoracic esophageal cancer (UTEC) using radiobiological evaluation. METHODS Computed tomography simulation data sets for 25 patients pathologically diagnosed with primary UTEC were used in this study. DE-I...

The purpose of this study is to apply noncoplanar intensity-modulated radiation therapy (Nonco_IMRT) to young female patients with mediastinal lymphoma. Nonco_IMRT was evaluated through a planning comparison study with coplanar IMRT (Co_IMRT) and conventional anteroposterior and posteroanterior fields (AP-PA) plans. Co_IMRT was performed with five equally spaced beams starting from a gantry ang...