Objective(s): Recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. Although 177Lutriethylene tetramine hexa methylene phosphonic acid (abbreviated as 177Lu- TTHMP), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. In this study,...

The authors wish to thank Nathaniel Schenker and Pei-Lu Chiu, whose detailed reviews and comments helped us to make many improvements to this report. In addition, special thanks to Dr. Schenker for permission to borrow text from his report (with Trivellore E. Raghunathan, Pei-Lu Chiu, Diane M. Makuc, Guangyu Zhang, and Alan J. Cohen) on the multiple imputation of family income and personal earn...

Processing of G4 DNA by Dna2 Helicase/Nuclease and RPA Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition Taro Masuda-Sasa, Piotr Polaczek, Xiao P. Peng, Lu Chen and Judith L. Campbell Braun Laboratories, 147-75, California Institute of Technology, Pasadena, CA 91125 Running title: Dna2/RPA/G4 interactions

J Thorac Cardiovasc Surg Ninomiya, Motohiko Osako and Hiroji Imamura Kejie Lu, Hajime Otani, Tadashi Yamamura, Yoshihisa Nakao, Reiji Hattori, Hideki preconditioning and potassium cardioplegia Protein kinase C isoform–dependent myocardial protection by ischemic http://jtcs.ctsnetjournals.org/cgi/content/full/121/1/0137 the World Wide Web at: The online version of this article, along with update...

MOSER-TRUDINGER AND ADAMS TYPE INEQUALITIES AND THEIRAPPLICATIONSbyNGUYEN LAMAugust 2014Advisor: Dr. Guozhen LuMajor: MathematicsDegree: Doctor of PhilosophyIn this dissertation, we study some variants of the Moser-Trudinger inequalities and Adamsinequalities. The proofs of these inequalities relied crucially on the symmetrization arguments inthe lite...

Radioimmunotherapy (RIT) of Non-Hodgkin's lymphoma (NHL) is said to be more advantageous compared to unlabelled therapeutic antibodies. To this date, radiolabelled murine anti-CD20 mAbs, Zevalin® and Bexxar® have been approved for imaging and therapy. A preparation containing rituximab, chimeric mAb radio immunoconjugate suitable for Lu-177 labeling, could provide better imaging and therapeutic...

PURPOSE Patient-specific dosimetry of lutetium-177 ((177)Lu)-DOTATATE treatment in neuroendocrine tumours is important, because uptake differs across patients. Single photon emission computer tomography (SPECT)-based dosimetry requires a conversion factor between the obtained counts and the activity, which depends on the collimator type, the utilized energy windows and the applied scatter corre...

Abstract A simple sublimation technology for the lutetium and ytterbium separation was proposed, which already at stage of preliminary experiments showed effectiveness: (a) completeness Yb resulted in short-term thermal annealing is least 98%, distilled product completely free from 177 Lu, no additional preparation repeated irradiation required ; (b) traditional ion-exchange chromatography can ...

In recent years, radiolabeled tracers targeting prostate-specific membrane antigen (PSMA) have had a tremendous impact on prostate cancer management. Here, we report the formation of radioactive impurities formed during clinical production 177Lu-labeled PSMA-617. We provide compelling evidence that these are result spontaneous, thermally mediated condensation reaction Glu-CO-Lys moiety resultin...