UNLABELLED One mechanism of resistance to trastuzumab in human epidermal growth factor receptor-2 (HER2)-positive breast cancer (BC) is increased epidermal growth factor receptor (EGFR) expression. We have developed (111)In-labeled bispecific radioimmunoconjugates (bsRICs) that bind HER2 and EGFR on BC cells by linking trastuzumab Fab fragments through a polyethylene glycol (PEG24) spacer to ep...

In the present paper, by considering the notion of MV-modules which is the structure that naturally correspond to lu-modules over lu-rings, we prove some results on prime A-ideals and state some conditions to obtain a prime A-ideal in MV-modules. Also, we state some conditions that an A-ideal is not prime and investigate conditions that $Ksubseteq bigcup _{i=1}^{n}K_{i}$ implies $Ksubseteq K_{j...

The coordination properties of the ligand 2,2'-bipyrimidine-4,4'-dicarboxylic acid (H2bpd) with lanthanide(III) ions (Ln = Eu, Tb, or Lu) were investigated. syntheses H2bpd and its salts, [K2(bpd)(H2O)2] (1) [(AlkNH)Lu(bpd)2] (Alk Et, Hex, en), are described. In presence LnCl3 salts Lu, Tb), formation [Ln(bpd)2]- [Ln(bpd)(H2O)x]+ species was assessed by 1H nuclear magnetic resonance (NMR), spec...

1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine (Lu AA21004) is a novel antidepressant that is currently in late-stage clinical development for major depressive disorder. In the present study, the metabolism of Lu AA21004 was investigated using human liver microsomes (HLM), human liver S9 fraction, and recombinant enzymes. Lu AA21004 was found in vitro to be oxidized to a 4-hydroxy-phenyl...

BACKGROUND Endothelin A (ETA) receptor antagonists have been shown to improve ventricular remodeling and survival in rats when started 10 days after infarction. Whether starting them earlier would have a more or less beneficial effect is uncertain. METHODS AND RESULTS Rats surviving an acute myocardial infarction (MI) for 24 hours (n=403) were assigned to saline or the ETA receptor antagonist...

Local hyperthermia and the hypoxic cytotoxin SR 4233 were administered to nude mice with 693 +/- 47 mm3 (mean +/- SE) s.c. HCT-8 human colonic adenocarcinoma xenografts in an attempt to enhance the antitumor effects of radioimmunotherapy. Biodistribution studies revealed preferential binding of NR-Lu-10, a murine monoclonal antibody, to the tumors compared with an isotype-matched control antibo...

AMA Lv L, Zhang M. Up-to-date literature review and issues of sedation during digestive endoscopy. Videosurgery Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. 2023. doi:10.5114/wiitm.2023.127854. APA Lv, L., & Zhang, (2023). https://doi.org/10.5114/wiitm.2023.127854 Chicago Lu-Lu, Meng-Meng Zhang. "Up-to-date endoscopy". Harvard MLA Lu-Lu et al. endoscopy." małoinwa...